Lysosomes are of major importance for the regulation of cellular cholesterol homeostasis.
Food-derived cholesterol and cholesterol esters contained within lipoproteins are delivered …

Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

The cGAS-STING signaling plays an integral role in the host immune response, and the
abnormal activation of cGAS-STING is highly related to various autoimmune diseases …

As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …

Microglia, the resident immune cells of the central nervous system, are not a homogeneous
population; their morphology, molecular profile, and even their ultrastructure greatly vary …

Abstract Background Niemann-Pick Disease Type C1 (NPC1) is a disorder of intracellular
cholesterol and lipid trafficking that leads to the accumulation of cholesterol and lipids in the …

Recent advances in protein structure prediction using machine learning such as AlphaFold2
and RosettaFold presage a revolution in structural biology. Genome-wide predictions of …

Abstract Purpose Niemann-Pick disease type C1 (NPC1) is a neurodegenerative lysosomal
disorder caused by pathogenic variants in NPC1. Disease progression is monitored using …

Microglia are resident myeloid cells in the central nervous system (CNS) with a unique
developmental origin, playing essential roles in developing and maintaining the CNS …

Macroautophagy/autophagy is a lysosome-dependent catabolic pathway for the degradation
of intracellular proteins and organelles. Autophagy dysfunction is related to many diseases …