Since the initial clinical approval in the late 1990s and remarkable anticancer effects for
certain types of cancer, molecular targeted therapy utilizing small molecule agents or …

Enhancers are genomic sequences that play a key role in regulating tissue-specific gene
expression levels. An increasing number of diseases are linked to impaired enhancer …

Childhood trauma (CT) can have persistent effects on the brain and is one of the major risk
factors for neuropsychiatric diseases in adulthood. Recent advances in the field of …

Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …

Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …

Diabetes is now considered as a 'silent epidemic'that claims over four million lives every
year, and the disease knows no socioeconomic boundaries. Despite extensive efforts by the …

Simple Summary Tumor-associated antigens (TAAs) are antigens present in tumor cells, but
are also expressed in normal cells. However, TAAs are aberrantly expressed by tumor cells …

So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Histone deacetylases (HDACs) are enzymes pursued as drug targets in various cancers and
several non-oncological conditions, such as inflammation and neurodegenerative disorders …

Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …