Transcriptome analysis is used to study gene expression in human tissues. It can promote
the discovery of new therapeutic targets for related diseases by characterizing the endocrine …

Simple Summary Pancreatic cancer, notorious for its aggressive nature and complex
desmoplastic tumor microenvironment, poses substantial treatment challenges, particularly …

Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors, and high
recurrence and metastasis are the major obstacles to successful treatment of HCC …

The c-mesenchymal-epithelial transition factor (c-MET) is involved in the tumorigenesis of
various cancers. HGF/Met inhibitors are now attracting considerable interest due to their anti …

Pancreatic ductal adenocarcinoma (PDAC) is a challenge for global health with very low
survival rate and high therapeutic resistance. Hence, advanced preclinical models for …

Metastatic cancer cells are highly plastic for the expression of different tumor phenotype
hallmarks and organotropism. This plasticity is highly regulated but the dynamics of the …

Gastrointestinal stromal tumors (GISTs) are the most common type of mesenchymal tumor in
the gastrointestinal tract. The present study aimed to identify the potential candidate …

Background: Cancer is the abnormal growth of cells in the body due to an imbalance in the
normal apoptotic pathways. The abnormality in the cancer cells makes them malignant …

Even though the tumour suppressive role of PTEN is well-known, its prognostic implications
are ambiguous. The objective of this study was to further explore the function of PTEN …

The hepatocyte growth factor (HGF) and its tyrosine kinase receptor cMET (MET proto-
oncogene) entered into the spotlight mainly as a bypassing pathway for other targeted …