[HTML][HTML] Novel approaches for vaccine development
MS Gebre, LA Brito, LH Tostanoski, DK Edwards… - Cell, 2021 - cell.com
Vaccines are critical tools for maintaining global health. Traditional vaccine technologies
have been used across a wide range of bacterial and viral pathogens, yet there are a …
have been used across a wide range of bacterial and viral pathogens, yet there are a …
[HTML][HTML] Tools for translation: non-viral materials for therapeutic mRNA delivery
KA Hajj, KA Whitehead - Nature Reviews Materials, 2017 - nature.com
In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …
[HTML][HTML] Improving mRNA-based therapeutic gene delivery by expression-augmenting 3′ UTRs identified by cellular library screening
AGO von Niessen, MA Poleganov, C Rechner… - Molecular Therapy, 2019 - cell.com
Synthetic mRNA has emerged as a powerful tool for the transfer of genetic information, and it
is being explored for a variety of therapeutic applications. Many of these applications require …
is being explored for a variety of therapeutic applications. Many of these applications require …
HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing
SA Yukl, P Kaiser, P Kim, S Telwatte, SK Joshi… - Science translational …, 2018 - science.org
Latently infected CD4+ T cells are the main barrier to complete clearance of HIV infection,
but it is unclear what mechanisms govern latent HIV infection in vivo. To address this …
but it is unclear what mechanisms govern latent HIV infection in vivo. To address this …
Alternative cleavage and polyadenylation: extent, regulation and function
The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
Engineered nucleic acids encoding a modified erythropoietin and their expression
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
AU-rich elements and associated factors: are there unifying principles?
C Barreau, L Paillard, HB Osborne - Nucleic acids research, 2005 - academic.oup.com
The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …
also rapidly adjust, the expression of regulatory factors whose over expression may be …
Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells
S Holtkamp, S Kreiter, A Selmi, P Simon, M Koslowski… - Blood, 2006 - ashpublications.org
Adoptive transfer of dendritic cells (DCs) transfected with in vitro–transcribed, RNA-
encoding, tumor-associated antigens has recently entered clinical testing as a promising …
encoding, tumor-associated antigens has recently entered clinical testing as a promising …
Terminally modified RNA
T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Engineered nucleic acids and methods of use thereof
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