In this review, the authors discuss the underlying principles of SHG and specific factors that
affect the generation properties and describe the essential components of a SHG instrument …

The majority of patients with osteogenesis imperfecta (OI) have mutations in the COL1A1 or
COL1A2 gene, which has consequences for the composition of the bone matrix and bone …

Second-harmonic generation (SHG) microscopy began to emerge as a high-resolution
optical imaging modality in the late 1990s, about 10 years after two-photon excited …

The inherited skeletal dysplasia osteogenesis imperfecta (OI) results in multiple fractures
and is currently treated empirically. We transplanted human first-trimester fetal blood …

We report the integrated use of 3D second harmonic generation (SHG) imaging microscopy
and Monte Carlo simulation as a combined metric to quantifiably differentiate normal and …

Bisphosphonates (BPs) avidly bind to calcium crystals and inhibit osteoclastic bone
resorption, making them useful for treatment of skeletal disorders such as osteoporosis …

Osteogenesis imperfecta (OI) is a debilitating clinical condition characterized by fragile bone
and skeletal deformity. Over the past decade frequent reports have suggested that the …

Pamidronate (PAM) infusion is the standard treatment in children with osteogenesis
imperfecta (OI). Zoledronic acid (ZOL) is a bisphosphonate with higher potency and faster …

Bone is a complex material with a hierarchical multi-scale organization from the molecule to
the organ scale. The genetic bone disease, osteogenesis imperfecta, is primarily caused by …

Background: Hypophosphatasia (HPP) is a rare, heritable, metabolic bone disease due to
deficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase. The infantile …