Microorganisms are known as important sources of natural compounds that have been
studied and applied for different purposes in distinct areas. Specifically, in the …

Highlights•Natural products offer a broad chemical catalog for bio-based product
development.•Genome mining tools for identifying BGCs.•Isoprenoid, nonribosomal peptide …

Azaserine, a natural product containing a diazo group, exhibits anticancer activity. In this
study, we investigated the biosynthetic pathway to azaserine. The putative azaserine …

Time span in literature: 1985-early 2024Natural products play a key role in drug discovery,
both as a direct source of drugs and as a starting point for the development of synthetic …

Mass spectrometry-based dereplication and prioritization led to the discovery of four multi-N-
methylated cyclodecapeptides, auyuittuqamides E–H (1–4), from a soil-derived …

Abstract N-methyltransferase (NMT)-catalyzed methylation at the termini of nonribosomal
peptides (NRPs) has rarely been reported. Here, we discover a fungal NMT LcsG for the …

Unnatural product (uNP) nonribosomal peptides promise to be a valuable source of
pharmacophores for drug discovery. However, the extremely large size and complexity of …

Natural products are small molecules synthesized by fungi, bacteria and plants, which
historically have had a profound effect on human health and quality of life. These natural …

Covering: 1997 to July 2023The adenylation reaction has been a subject of scientific
intrigue since it was first recognized as essential to many biological processes, including the …

Eco-friendly bioherbicides are urgently needed for managing the problematic weed
Amaranthus retroflexus. A mass spectrometry-and bioassay-guided screening approach …