Regulation of gene expression is a complex but highly guided process. While genomic
technologies and computational approaches have allowed high-throughput mapping of cis …

Liquid‒liquid phase separation (LLPS) is a general phenomenon recently recognized to be
critically involved in the regulation of a variety of cellular biological processes, such as …

Biomolecular condensates play key roles in various biological processes. However, specific
condensation modulators are currently lacking. PROTAC is a new technology that can use …

Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate that is present in
nearly all organisms studied to date. A remarkable function of polyP involves its attachment …

Many transcription factors (TFs) localize in nuclear clusters of locally increased
concentrations, but how TF clustering is regulated and how it influences gene expression is …

Background Tumor-associated macrophages are mainly polarized into the M2 phenotype,
remodeling the tumor microenvironment and promoting tumor progression by secreting …

Liquid–liquid phase separation (LLPS) plays a critical role in regulating gene transcription
via the formation of transcriptional condensates. However, LLPS has not been reported to be …

Abstract Methyltransferase-like protein 3 (METTL3) plays critical roles in acute myeloid
leukemia (AML) progression, however, the mechanism of abnormal overexpression of …

Intrinsically disordered regions (IDRs) in DNA-associated proteins are known to influence
gene regulation, but their distribution and cooperative functions in genome-wide regulatory …

Abstract G-quadruplexes (G4s) can recruit transcription factors to activate gene expression,
but detailed mechanisms remain enigmatic. Here, we demonstrate that G4s in the CCND1 …