Targeting mitochondrial function to protect against vision loss

J Chhetri, N Gueven - Expert Opinion on Therapeutic Targets, 2016 - Taylor & Francis
Introduction: Mitochondria, essential to multicellular life, convert food into ATP to satisfy
cellular energy demands. Since different tissues have different energy requirements …

An updated review on the most common agents causing toxic optic neuropathies

W Wasinska-Borowiec, K Abri Aghdam… - Current …, 2017 - ingentaconnect.com
Background: Toxic optic neuropathies (TONs) often present with a gradual and bilateral
decrease in visual acuity, scotomas and optic disc pallor. Obtaining an accurate history is …

Amiodarone-induced retinal neuronal cell apoptosis attenuated by IGF-1 via counter regulation of the PI3k/Akt/FoxO3a pathway

R Liao, F Yan, Z Zeng, M Farhan, P Little… - Molecular …, 2017 - Springer
Amiodarone (AM) is the most effective antiarrhythmic agent currently available. However,
clinical application of AM is limited by its serious toxic adverse effects including optic …

[HTML][HTML] Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2 …

C Yang, X Zhao, W Zhou, Q Li, P Lazarovici… - Journal of Translational …, 2024 - Springer
Background Ocular toxicity is a severe adverse effect that limits the chronic clinical use of the
antiarrhythmic drug amiodarone. Here, we aimed to evaluate the cytoprotective effect of …

Insulin‐like growth factor‐1 activates PI3K/Akt signalling to protect human retinal pigment epithelial cells from amiodarone‐induced oxidative injury

R Liao, F Yan, Z Zeng, H Wang, K Qiu… - British Journal of …, 2018 - Wiley Online Library
Background and Purpose Amiodarone is one of the most effective anti‐arrhythmic drugs
available, but its clinical applications are limited by toxic side effects including optic toxicity …

[HTML][HTML] Bio-spectroscopic investigation linking changes of retinal structure with short-term administration of Amiodarone and revealing the ameliorative effect of …

SS Mahmoud, SA Morsy, EM Aly, IA Mohalhal - Scientific Reports, 2024 - nature.com
Long term use of Amiodarone (AMIO) is associated with the development of ocular adverse
effects. This study investigates the short term effects, and the ameliorative consequence of …

[HTML][HTML] Low-dose amiodarone is safe: a systematic review and meta-analysis

R Chokesuwattanaskul, N Shah… - The Journal of …, 2020 - ncbi.nlm.nih.gov
Amiodarone is commonly used for a variety of arrhythmias and, in some parts of the world, is
the only available antiarrhythmic drug (AAD). Yet, amiodarone is known to have a wide …

[HTML][HTML] Behaviour of disc oedema during and after amiodarone optic neuropathy: case report

MA Martínez-LóPez-Portillo… - Journal of Clinical …, 2014 - ncbi.nlm.nih.gov
A 73-year-old woman with atrial fibrillation treated with Amiodarone presented with Optic
Disc oedema in right eye (OD). Using Optical Coherence Tomography (OCT) we describe …

Short-term treatment with oral amiodarone resulting in bilateral optic neuropathy and permanent blindness

A Knudsen - Case Reports, 2017 - casereports.bmj.com
A 66-year-old man was hospitalised due to worsening of his atrial fibrillation, and
successfully underwent an electrocardioversion to restore sinus rhythm. He was discharged …

Prospective induction of peripheral neuropathy by the use of Tartarian Buckwheat

F Yang, S Yu, Y Wang, R Wang, F Jing - Journal of the Neurological …, 2014 - Elsevier
Tartarian Buckwheat is an effective hypoglycemic medicinal herb. Its main active ingredients
are flavonoids. We report here 5 cases of new onset polyneuropathy with dyskinesia …