Tobacco smoke carcinogens and lung cancer

SS Hecht - Journal of the national cancer institute, 1999 - academic.oup.com
The complexity of tobacco smoke leads to some confusion about the mechanisms by which
it causes lung cancer. Among the multiple components of tobacco smoke, 20 carcinogens …

[PDF][PDF] Morinda citrifolia (Noni): a literature review and recent advances in Noni research

MY Wang, BJ West, CJ Jensen, D Nowicki… - Acta Pharmacologica …, 2002 - academia.edu
Morinda citrifolia L (Noni) has been used in folk remedies by Polynesians for over 2000
years, and is reported to have a broad range of therapeutic effects, including antibacterial …

Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition

B Halliwell - Mutation Research/Genetic Toxicology and …, 1999 - Elsevier
Humans are exposed to many carcinogens, but the most significant may be the reactive
species derived from metabolism of oxygen and nitrogen. Nitric oxide seems unlikely to …

Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer

SS Hecht - Carcinogenesis, 2002 - academic.oup.com
Measurement of human urinary carcinogen metabolites is a practical approach for obtaining
important information about tobacco and cancer. This review presents currently available …

Effect of diet on cancer development: is oxidative DNA damage a biomarker?

B Halliwell - Free Radical Biology and Medicine, 2002 - Elsevier
Free radicals and other reactive species are generated in vivo and many of them can cause
oxidative damage to DNA. Although there are methodological uncertainties about accurate …

[HTML][HTML] Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come?

B Halliwell - The American journal of clinical nutrition, 2000 - Elsevier
Free radicals and other reactive species are constantly generated in vivo and cause
oxidative damage to DNA at a rate that is probably a significant contributor to the age-related …

An approach to investigating the importance of high potency polycyclic aromatic hydrocarbons (PAHs) in the induction of lung cancer by air pollution

KB Okona-Mensah, J Battershill, A Boobis… - Food and chemical …, 2005 - Elsevier
Evidence suggests that people living in urban areas have an increased risk of lung cancer
due to higher levels of air pollution in these areas. Benzo [a] pyrene (B [a] P) is currently …

Biomarkers as biological indicators of xenobiotic exposure

F Gil, A Pla - Journal of Applied Toxicology: An International …, 2001 - Wiley Online Library
The presence of a xenobiotic in the environment always represents a risk for living
organisms. However, to talk about impregnation there is a need to detect toxicity in the …

Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies

B Halliwell - Free radical research, 1998 - Taylor & Francis
Damage to DNA by oxygen radicals and other reactive oxygen/nitrogen/chlorine species
occurs in vivo despite the presence of multiple antioxidant defence and repair systems. Such …

Oxidative DNA damage: biological significance and methods of analysis

G Guetens, GD Boeck, M Highley… - Critical reviews in …, 2002 - Taylor & Francis
All forms of aerobic life are subjected constantly to oxidant pressure from molecular oxygen
and also reactive oxygen species (ROS), produced during the biochemical utilization of O2 …