Adjuvants: Classification, Modus Operandi, and Licensing

JS Apostolico, VAS Lunardelli… - Journal of …, 2016 - Wiley Online Library
Vaccination is one of the most efficient strategies for the prevention of infectious diseases.
Although safer, subunit vaccines are poorly immunogenic and for this reason the use of …

Vaccines, adjuvants and key factors for mucosal immune response

VA Correa, AI Portilho, E De Gaspari - Immunology, 2022 - Wiley Online Library
Vaccines are the most effective tool to control infectious diseases, which provoke significant
morbidity and mortality rates. Most vaccines are administered through the parenteral route …

Mucosal vaccine delivery: Current state and a pediatric perspective

AK Shakya, MYE Chowdhury, W Tao, HS Gill - Journal of controlled release, 2016 - Elsevier
Most childhood infections occur via the mucosal surfaces, however, parenterally delivered
vaccines are unable to induce protective immunity at these surfaces. In contrast, delivery of …

DNA vaccines: history, molecular mechanisms and future perspectives

S Pagliari, B Dema, A Sanchez-Martinez… - Journal of Molecular …, 2023 - Elsevier
The history of DNA vaccine began as early as the 1960s with the discovery that naked DNA
can transfect mammalian cells in vivo. In 1992, the evidence that such transfection could …

Flagellin as a vaccine adjuvant

B Cui, X Liu, Y Fang, P Zhou, Y Zhang… - Expert review of …, 2018 - Taylor & Francis
Introduction: Bacterial flagellin, as a pathogen-associated molecular pattern (PAMP), can
activate both innate and adaptive immunity. Its unique structural characteristics endow an …

Chitosan: a promising safe and immune-enhancing adjuvant for intranasal vaccines

A Smith, M Perelman, M Hinchcliffe - Human vaccines & …, 2014 - Taylor & Francis
The nasal route is attractive for the delivery of vaccines in that it not only offers an easy to
use, non-invasive, needle-free alternative to more conventional parenteral injection, but it …

Considerations for size, surface charge, polymer degradation, co‐delivery, and manufacturability in the development of polymeric particle vaccines for infectious …

CJ Genito, CJ Batty, EM Bachelder… - Advanced …, 2021 - Wiley Online Library
Vaccines have advanced human health for centuries. To improve upon the efficacy of
subunit vaccines they have been formulated into nano/microparticles for infectious diseases …

Current progress and challenges in the study of adjuvants for oral vaccines

B Ou, Y Yang, H Lv, X Lin, M Zhang - BioDrugs, 2023 - Springer
Over the past 20 years, a variety of potential adjuvants have been studied to enhance the
effect of oral vaccines in the intestinal mucosal immune system; however, no licensed …

Recent mechanistic insights on glycoconjugate vaccines and future perspectives

F Berti, R Adamo - ACS Chemical Biology, 2013 - ACS Publications
Vaccination is a key strategy for the control of various infectious diseases. Many pathogens,
such as Streptococcus pneumoniae, Haemophilus influenzae type b (Hib), and Neisseria …

[PDF][PDF] One world, one health-veterinary perspectives

K Dhama, S Chakraborty, S Kapoor, R Tiwari… - Adv. Anim. Vet …, 2013 - academia.edu
One Health requires multidisciplinary efforts at global, national and local levels, for the sake
of our planet, mankind and animals. It was initiated at the American Veterinary Medical …