Mouse models of sarcopenia: classification and evaluation
W Xie, M He, D Yu, Y Wu, X Wang, S Lv… - Journal of cachexia …, 2021 - Wiley Online Library
Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an
increased possibility of adverse consequences such as falls, fractures, physical disabilities …
increased possibility of adverse consequences such as falls, fractures, physical disabilities …
The role of autophagy in skeletal muscle diseases
Q Xia, X Huang, J Huang, Y Zheng, ME March… - Frontiers in …, 2021 - frontiersin.org
Skeletal muscle is the most abundant type of tissue in human body, being involved in
diverse activities and maintaining a finely tuned metabolic balance. Autophagy …
diverse activities and maintaining a finely tuned metabolic balance. Autophagy …
[HTML][HTML] Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation
Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways.
The fusion of satellite cells, driven by cell‐autonomous and/or extrinsic factors, contributes …
The fusion of satellite cells, driven by cell‐autonomous and/or extrinsic factors, contributes …
Evolving roles of muscle-resident fibro-adipogenic progenitors in health, regeneration, neuromuscular disorders, and aging
Normal skeletal muscle functions are affected following trauma, chronic diseases, inherited
neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of …
neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of …
Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
Mammalian cells exhibit remarkable diversity in cell size, but the factors that regulate
establishment and maintenance of these sizes remain poorly understood. This is especially …
establishment and maintenance of these sizes remain poorly understood. This is especially …
Muscle-specific SMN reduction reveals motor neuron–independent disease in spinal muscular atrophy models
Paucity of the survival motor neuron (SMN) protein triggers the oft-fatal infantile-onset motor
neuron disorder, spinal muscular atrophy (SMA). Augmenting the protein is one means of …
neuron disorder, spinal muscular atrophy (SMA). Augmenting the protein is one means of …
PPARs and microbiota in skeletal muscle health and wasting
Skeletal muscle is a major metabolic organ that uses mostly glucose and lipids for energy
production and has the capacity to remodel itself in response to exercise and fasting …
production and has the capacity to remodel itself in response to exercise and fasting …
Myonuclear content regulates cell size with similar scaling properties in mice and humans
Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell
sizes are variable and adaptable, but what governs cell size has been unclear. We find that …
sizes are variable and adaptable, but what governs cell size has been unclear. We find that …
Verapamil mitigates chloride and calcium bi-channelopathy in a myotonic dystrophy mouse model
LA Cisco, MT Sipple, KM Edwards… - The Journal of …, 2024 - Am Soc Clin Investig
Myotonic dystrophy type 1 (DM1) involves misregulated alternative splicing for specific
genes. We used exon or nucleotide deletion to mimic altered splicing of genes central to …
genes. We used exon or nucleotide deletion to mimic altered splicing of genes central to …
The myonuclear domain in adult skeletal muscle fibres: past, present and future
Most cells in the body are mononuclear whereas skeletal muscle fibres are uniquely
multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which …
multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which …