Acute kidney injury (AKI) is a contributing factor in the development and progression of
chronic kidney disease (CKD). Despite rapid progresses, the mechanism underlying AKI …

Optimal tissue oxygenation is essential for its normal function. Suboptimal oxygenation or
ischemia contributes to increased mortalities during various pathological conditions such as …

Background. Leukocyte adhesion/infiltration in response to renal ischaemia/reperfusion (I/R)
injury is a well‐known but poorly understood phenomenon. The identification, kinetics, and …

BACKGROUND Longitudinal investigations of murine acute kidney injury (AKI) suggest that
injury and inflammation may persist long after the initial insult. However, the evolution of …

MAPK activities, including JNK, p38, and ERK, are markedly enhanced after ischemia in
vivoand chemical anoxia in vitro. The relative extent of JNK, p38, or ERK activation has been …

There is an emerging concept in clinical nephrology that acute kidney injury (AKI) can
initiate chronic kidney disease (CKD). However, potential mechanisms by which this may …

Acute kidney injury (AKI), commonly caused by ischemia-reperfusion injury, has far-reaching
health consequences. Despite the significant regenerative capacity of proximal tubular …

This study assessed whether endothelin-1 (ET-1) helps mediate postischemic acute kidney
injury (AKI) progression to chronic kidney disease (CKD). The impact (s) of potent ETA or …

Unilateral ischemia-reperfusion (UIR) injury leads to progressive renal atrophy and
tubulointerstitial fibrosis (TIF) and is commonly used to investigate the pathogenesis of the …

Discussion DR. THOMAS H. HOSTETTER (Director, Division of Renal Diseases and
Hypertension, and Professor of Medicine, University of Minnesota Medical School …