Prostate cancer (PCa) is the most common cancer in men. The androgen receptor (AR) has
a pivotal role in the pathogenesis and progression of PCa. Many therapies targeting AR …

Steroid hormone signaling induces vast gene expression programs which necessitate the
local formation of transcription factories at regulatory regions and large-scale alterations of …

Aberrant androgen receptor (AR) signaling drives prostate cancer (PC), and it is a key
therapeutic target. Although initially effective, the generation of alternatively spliced AR …

Simple Summary Prostate cancer can develop under hormone treatment and chemotherapy
from a castration-sensitive towards a castration-resistant into a drug resistant-tumor. The …

Prostate cancer (PC), the second most prevalent malignancy in men worldwide, has been
proven to depend on the aberrant activation of androgen receptor (AR) signaling. Long-term …

Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of
the androgen receptor (AR) signaling axis since Huggins et al. discovered that …

Androgenetic alopecia (AGA) is the most common nonscarring alopecia and is
characterised by distinct gradual patterned hair loss. AGA is mediated by genetic …

Steroid receptors (SRs) are members of the nuclear receptor family, which are ligand-
activated transcription factors. SRs regulate many physiological functions including …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

Background. EPI-506 is the first of a new class of drugs targeting the N-terminal domain
(NTD) of the androgen receptor (AR), potentially overcoming known resistance mechanisms …