Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection

T Charalampous, GL Kay, H Richardson, A Aydin… - Nature …, 2019 - nature.com
The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …

Transmission of diverse oral bacteria to murine placenta: evidence for the oral microbiome as a potential source of intrauterine infection

Y Fardini, P Chung, R Dumm, N Joshi… - Infection and …, 2010 - Am Soc Microbiol
Microbial infection of the intrauterine environment is a major cause of preterm birth. The
current paradigm indicates that intrauterine infections predominantly originate from the …

De novo identification of microbial contaminants in low microbial biomass microbiomes with Squeegee

Y Liu, RAL Elworth, MD Jochum, KM Aagaard… - Nature …, 2022 - nature.com
Computational analysis of host-associated microbiomes has opened the door to numerous
discoveries relevant to human health and disease. However, contaminant sequences in …

Lung infections in cystic fibrosis: deriving clinical insight from microbial complexity

GB Rogers, FA Stressmann, AW Walker… - Expert review of …, 2010 - Taylor & Francis
Lower respiratory tract bacterial infections, such as those associated with cystic fibrosis lung
disease, represent a major healthcare burden. Treatment strategies are currently informed …

Oral microbiome variations related to ageing: possible implications beyond oral health

A Kazarina, J Kuzmicka, S Bortkevica, P Zayakin… - Archives of …, 2023 - Springer
The global population is getting older due to a combination of longer life expectancy and
declining birth rates. Growing evidence suggests that the oral microbiota composition and …

Rare concurrent retroclival and pan-spinal subdural empyema: review of literature with an uncommon illustrative case

MM Mortazavi, SA Quadri, SS Suriya, SA Fard… - World Neurosurgery, 2018 - Elsevier
Background Subdural empyema can present as a spinal subdural empyema (SSE) or a
cranial subdural empyema (CSE). Although they differ somewhat in epidemiology, etiology …

Respiratory immune status and microbiome in recovered COVID-19 patients revealed by metatranscriptomic analyses

H Meng, S Wang, X Tang, J Guo, X Xu… - Frontiers in Cellular …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is currently a severe threat to global public health,
and the immune response to COVID-19 infection has been widely investigated. However …

Rapid diagnosis of lower respiratory infection using nanopore-based clinical metagenomics

T Charalampous, H Richardson, GL Kay, R Baldan… - BioRxiv, 2018 - biorxiv.org
Lower respiratory infections (LRIs) accounted for three million deaths worldwide in 2016, the
leading infectious cause of mortality. The “gold standard” for investigation of bacterial LRIs is …

Streptococcus Oralis meningitis from right sphenoid Meningoencephalocele and cerebrospinal fluid leak

K Patel, Z Memon, A Prince, C Park, A Sajan… - BMC Infectious …, 2019 - Springer
Background Streptococcus oralis belongs to the Streptococcus mitis group and is part of the
normal flora of the nasal and oropharynx (Koneman et al., The Gram-positive cocci part II …

Urgent vitrectomy with vancomycin infusion, silicone oil endotamponade, and general antibiotic treatment in multiple cases of endophthalmitis from a single day of …

A Pietras-Baczewska, E Jasińska, MD Toro… - Journal of Clinical …, 2021 - mdpi.com
The aim of this study was to report on the anatomical and functional results of surgical
management of seven cases of endophthalmitis related to a single day of intravitreal …