Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection
The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …
Transmission of diverse oral bacteria to murine placenta: evidence for the oral microbiome as a potential source of intrauterine infection
Y Fardini, P Chung, R Dumm, N Joshi… - Infection and …, 2010 - Am Soc Microbiol
Microbial infection of the intrauterine environment is a major cause of preterm birth. The
current paradigm indicates that intrauterine infections predominantly originate from the …
current paradigm indicates that intrauterine infections predominantly originate from the …
De novo identification of microbial contaminants in low microbial biomass microbiomes with Squeegee
Computational analysis of host-associated microbiomes has opened the door to numerous
discoveries relevant to human health and disease. However, contaminant sequences in …
discoveries relevant to human health and disease. However, contaminant sequences in …
Lung infections in cystic fibrosis: deriving clinical insight from microbial complexity
Lower respiratory tract bacterial infections, such as those associated with cystic fibrosis lung
disease, represent a major healthcare burden. Treatment strategies are currently informed …
disease, represent a major healthcare burden. Treatment strategies are currently informed …
Oral microbiome variations related to ageing: possible implications beyond oral health
A Kazarina, J Kuzmicka, S Bortkevica, P Zayakin… - Archives of …, 2023 - Springer
The global population is getting older due to a combination of longer life expectancy and
declining birth rates. Growing evidence suggests that the oral microbiota composition and …
declining birth rates. Growing evidence suggests that the oral microbiota composition and …
Rare concurrent retroclival and pan-spinal subdural empyema: review of literature with an uncommon illustrative case
Background Subdural empyema can present as a spinal subdural empyema (SSE) or a
cranial subdural empyema (CSE). Although they differ somewhat in epidemiology, etiology …
cranial subdural empyema (CSE). Although they differ somewhat in epidemiology, etiology …
Respiratory immune status and microbiome in recovered COVID-19 patients revealed by metatranscriptomic analyses
H Meng, S Wang, X Tang, J Guo, X Xu… - Frontiers in Cellular …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is currently a severe threat to global public health,
and the immune response to COVID-19 infection has been widely investigated. However …
and the immune response to COVID-19 infection has been widely investigated. However …
Rapid diagnosis of lower respiratory infection using nanopore-based clinical metagenomics
T Charalampous, H Richardson, GL Kay, R Baldan… - BioRxiv, 2018 - biorxiv.org
Lower respiratory infections (LRIs) accounted for three million deaths worldwide in 2016, the
leading infectious cause of mortality. The “gold standard” for investigation of bacterial LRIs is …
leading infectious cause of mortality. The “gold standard” for investigation of bacterial LRIs is …
Streptococcus Oralis meningitis from right sphenoid Meningoencephalocele and cerebrospinal fluid leak
K Patel, Z Memon, A Prince, C Park, A Sajan… - BMC Infectious …, 2019 - Springer
Background Streptococcus oralis belongs to the Streptococcus mitis group and is part of the
normal flora of the nasal and oropharynx (Koneman et al., The Gram-positive cocci part II …
normal flora of the nasal and oropharynx (Koneman et al., The Gram-positive cocci part II …
Urgent vitrectomy with vancomycin infusion, silicone oil endotamponade, and general antibiotic treatment in multiple cases of endophthalmitis from a single day of …
A Pietras-Baczewska, E Jasińska, MD Toro… - Journal of Clinical …, 2021 - mdpi.com
The aim of this study was to report on the anatomical and functional results of surgical
management of seven cases of endophthalmitis related to a single day of intravitreal …
management of seven cases of endophthalmitis related to a single day of intravitreal …