The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …

Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …

It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …

Neurodegenerative diseases of the central nervous system (CNS) are characterized by
progressive neuronal death and neurological dysfunction, leading to increased disability …

Brain derived neurotrophic factor (BDNF) has multiple biological functions which are
mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor …

Highlights•Neurotrophins have been linked to several disorders, including AD and
depression.•Complex biology has led to difficulties in identifying suitable drug …

In the past two decades, advances in sequencing technology and analysis of the human and
mouse genome have led to the discovery of many non-protein-coding RNAs (ncRNAs) …

Neurotrophins are a family of secreted proteins expressed in the peripheral nervous system
and the central nervous system that support neuronal survival, synaptic plasticity, and …