This article reviews the past and current statuses of time-domain near-infrared spectroscopy
(TD-NIRS) and imaging. Although time-domain technology is not yet widely employed due to …

Near‐infrared spectroscopy (NIRS), a noninvasive optical technique, can measure changes
in hemoglobin (Hb) concentrations in brain tissue. Jöbsis first described the in vivo …

We evaluate Photofrin-mediated photodynamic therapy (PDT) in a phase 2 clinical trial as
an adjuvant to surgery to treat peritoneal carcinomatosis. We extract tissue optical [reduced …

The in-vivo optical properties of the human head are investigated in the 600–1100 nm range
on different subjects using continuous wave and time domain diffuse optical spectroscopy …

We investigate the optical properties of the brain in 23 neonates in vivo using a frequency
domain near-infrared spectroscopy (NIRS). In this study, a calibration procedure is …

Using both experimental and theoretical methods, we examine the contribution of different
parts of the head to near-IR (NIR) signal. Time-resolved spectroscopy is employed to …

This book provides a comprehensive up-to-date review of optical approaches used in brain
imaging and therapy. It covers a variety of imaging approaches including diffuse optical …

A diffusion-based model for photon migration through a three-layer medium is described.
The main purpose of this work is to investigate the performance of a diffusion equation (DE) …

In this paper, the theories commonly used for the study of photon migration through
biological tissues and for biomedical applications are reviewed. The concepts of absorption …

Accurate assessment of light distributions in the brain is vital for both diagnostic and
therapeutic applications. This, in turn, requires knowledge of the optical properties of brain …