Human Brain In Vitro Model for Pathogen Infection-Related Neurodegeneration Study

Y Yan, AN Cho - International Journal of Molecular Sciences, 2024 - mdpi.com
Recent advancements in stem cell biology and tissue engineering have revolutionized the
field of neurodegeneration research by enabling the development of sophisticated in vitro …

Research models to study ferroptosis's impact in neurodegenerative diseases

I Costa, DJ Barbosa, V Silva, S Benfeito, F Borges… - Pharmaceutics, 2023 - mdpi.com
Ferroptosis is a type of regulated cell death promoted by the appearance of oxidative
perturbations in the intracellular microenvironment constitutively controlled by glutathione …

Chromatin accessibility in canine stromal cells and its implications for canine somatic cell reprogramming

M Questa, M Moshref, RJ Jimenez… - Stem cells …, 2021 - academic.oup.com
Naturally occurring disease in pet dogs is an untapped and unique resource for stem cell-
based regenerative medicine translational research, given the many similarities and …

Biochemical characterisation of Parkinson's disease models

H Alrashidi - 2022 - discovery.ucl.ac.uk
Parkinson's disease (PD) is the second most common neurodegenerative disorder. The
exact molecular mechanism of disease remains unclear. Several factors are proposed to …

[HTML][HTML] Automated algorithm development to assess survival of human neurons using longitudinal single-cell tracking: Application to synucleinopathy

J Choi, H Kii, J Nelson, Y Yamazaki, F Yanagawa… - SLAS technology, 2023 - Elsevier
The development of phenotypic assays with appropriate analyses is an important step in the
drug discovery process. Assays using induced pluripotent stem cell (iPSC)-derived human …

Modeling Neural Circuits in Parkinson's Disease

G Ameen, B Osama - Handbook of Neurodegenerative Disorders, 2023 - Springer
Parkinson's disease is one of the most customary neurodegenerative defects in this age. A
lot of motor symptoms appear in the patient as well as other non-motor symptoms …

Neuroprotective Screening of Natural Phenolics in an MPTP-Induced Model of Parkinson's Disease Using Zebrafish Larvae

F Hedayatikatouli - 2024 - ruor.uottawa.ca
This study investigates the neuroprotective effects of Ascorbic Acid (AA), Vanillic Acid (VA),
and Ferulic Acid (FA) in a zebrafish model of Parkinson's Disease (PD), induced by MPTP …

Evaluation of the anti-inflammatory potential of extracts methanolics from Catingueira (Cenostigma Bracteosum) and Canafistula (Senna Trachypus)

AIB da Silva, LE Nunes, LC de Oliveira, FP Guzen… - Peer Review, 2023 - peerw.org
The use of medicinal plants are ancient practices used by the population to prevent or treat
various types of diseases. In the Brazilian Northeast, the use of medicinal plants for the …

Neural tissue microphysiological systems in the era of patient-derived pluripotent stem cells

AE Mungenast, R Aron, JD White, DF Tardiff… - Microfluidic Cell Culture …, 2019 - Elsevier
Neurological conditions not only can be devastating to patients and families but also are
among the most difficult disorders for researchers to understand. More than 1 billion people …

Investigating the protein quality control pathways that prevent protein aggregation in the social amoeba Dictyostelium discoideum.

HN Haver - 2023 - search.proquest.com
A major hallmark of many neurodegenerative diseases is protein aggregation. Protein
aggregation occurs in part due to failure of protein quality control pathways. A better …