Growing evidence supports the pivotal role played by oxidative stress in tissue injury
development, thus resulting in several pathologies including cardiovascular, renal …

Diabetes mellitus is an increasingly common chronic medical condition. Approximately 30%
of diabetic patients develop neuropathic pain, manifested as spontaneous pain …

The transient receptor potential (TRP) family comprises a diverse group of cation channels
that regulate a variety of intracellular signaling pathways. The TRPV1 (vanilloid 1) channel is …

Transient receptor potential vanilloid type 1 channel (TRPV1), as a ligand-gated non-
selective cation channel, has recently been demonstrated to have wide expression in the …

Neuroinflammation is a critical pathophysiological hallmark of neurodegenerative disorders,
including Alzheimer's disease (AD), Parkinson's disease (PD), and traumatic brain injury …

The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key
cellular signalling systems that participate in the modulation of diverse cellular functions …

Painful peripheral neuropathy is a common dose-limiting side effect of chemotherapeutic
paclitaxel (PTX) treatment. The American Society of Clinical Oncology (ASCO) recommends …

Calcitonin gene‐related peptide (CGRP), substance P and dural mast cells are main
contributors in neurogenic inflammation underlying migraine pathophysiology. Modulation of …

Alzheimer's disease is the most common form of dementia, it is estimated to affect over 40
million people worldwide. Classically, the disease has been characterized by the …

Natural products and leads inspired by them have acted as a probe for successful drug
discovery for many decades. Pain is an obnoxious sensory and emotional experience …