Neurobiological mechanisms of nicotine reward and aversion
Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …
Addiction‐related neuroadaptations following chronic nicotine exposure
The addiction‐relevant molecular, cellular, and behavioral actions of nicotine are derived
from its stimulatory effects on neuronal nicotinic acetylcholine receptors (nAChRs) in the …
from its stimulatory effects on neuronal nicotinic acetylcholine receptors (nAChRs) in the …
Habenular α5 nicotinic receptor subunit signalling controls nicotine intake
Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor
subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying …
subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying …
[HTML][HTML] The predictive validity of the rat self-administration model for abuse liability
EC O'Connor, K Chapman, P Butler… - … & Biobehavioral Reviews, 2011 - Elsevier
The self-administration model is the primary non-clinical approach for assessing the
reinforcing properties of novel compounds. Given the now frequent use of rats in self …
reinforcing properties of novel compounds. Given the now frequent use of rats in self …
Effects of nicotine in experimental animals and humans: an update on addictive properties
BL Foll, SR Goldberg - Nicotine Psychopharmacology, 2009 - Springer
Tobacco use through cigarette smoking is the leading preventable cause of death in the
developed world. Nicotine, a psychoactive component of tobacco, appears to play a major …
developed world. Nicotine, a psychoactive component of tobacco, appears to play a major …
Effects of electronic cigarette liquid solvents propylene glycol and vegetable glycerin on user nicotine delivery, heart rate, subjective effects, and puff topography
Abstract Background Electronic cigarettes (ECIGs) are a class of tobacco products that
produce different effects (eg, nicotine delivery), depending on the device, liquid, and …
produce different effects (eg, nicotine delivery), depending on the device, liquid, and …
Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction
B Forget, A Pushparaj, B Le Foll - Biological psychiatry, 2010 - Elsevier
BACKGROUND: Nicotine is the principal component of tobacco smoke, resulting in
addiction, and recent evidence suggests that damage to the insular cortex (insula) disrupts …
addiction, and recent evidence suggests that damage to the insular cortex (insula) disrupts …
[HTML][HTML] Nicotine in senescence and atherosclerosis
Cigarette smoke is a known exacerbator of age-related pathologies, such as cardiovascular
disease (CVD), atherosclerosis, and cellular aging (senescence). However, the role of …
disease (CVD), atherosclerosis, and cellular aging (senescence). However, the role of …
Interactions between nicotine and drugs of abuse: a review of preclinical findings
SJ Kohut - The American Journal of Drug and Alcohol Abuse, 2017 - Taylor & Francis
Polysubstance abuse is common among substance-use disorder patients, and nicotine is
one of the most commonly co-used substances. Epidemiological and clinical laboratory …
one of the most commonly co-used substances. Epidemiological and clinical laboratory …
Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice
Neuronal nicotinic acetylcholine receptors (nAChRs) can regulate the activity of many
neurotransmitter pathways throughout the central nervous system and are considered to be …
neurotransmitter pathways throughout the central nervous system and are considered to be …