Drug dependence is a leading cause of negative health consequences and has enormous
societal impact. 1 Pharmacotherapies have been developed to target both the rewarding …

Abstract<? Pub Inc> The impact of'CYP2A6'and'CYP2B6'genetic variation on nicotine
metabolism, tobacco use behaviours, and nicotine biomarkers was investigated in a group …

Introduction: Tobacco use is a major economic and health problem. Particularly concerning
is that women consume more tobacco products, have a more difficult time quitting, and are …

A number of recent studies have found indicators of non-nicotine constituents in tobacco
products that drastically inhibit the brain enzyme monoamine oxidase (MAO). MAO inhibition …

Intravenous self-administration (IVSA) studies have shown that nicotine can serve as a
reinforcer in animals and humans. Brain mechanisms underlying nicotine IVSA, as well as …

This report presents the conclusions reached and recommendations made by the members
of the WHO Study Group on Tobacco Product Regulation at its sixth meeting, during which it …

Rationale: Peak initiation of smoking occurs during adolescence and early onset of smoking
is associated with a reduced probability of quitting and greater risk of relapse compared to …

We investigated the efficacy of standard (8-week nicotine, 16-week placebo) vs extended
(24-week nicotine) patch therapy for smoking cessation, and the effect of slow nicotine …

Plus de trois millions de morts sont attribués au tabagisme dans le monde par an, et l'usage
de tabac est en progression dans les pays en voie de développement. L'usage de tabac est …

Past research suggests that nicotine-induced increases in reinforced responding are due to
its reinforcer-enhancing effects. It is unclear whether this role is specific to certain kinds of …