Diabetic cardiomyopathy is a result of diabetes-induced changes in the structure and
function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but …

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among
patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications …

Macrovascular complications of diabetes, including diabetic cardiovascular disease (CVD),
occur through a number of hyperglycaemia-induced mechanisms that include generation of …

The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the
clinical management of gout and conditions associated with hyperuricemia for several …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Objectives: This study evaluated whether a xanthine oxidase (XO) inhibitor, oxypurinol,
produces clinical benefits in patients with New York Heart Association functional class III to …

Oxidative stress plays an important role in the progression of vascular endothelial
dysfunction. The two major systems generating vascular oxidative stress are the NADPH …

Background: Uric acid (UA) concentration within carotid plaque and its association with
cerebrovascular events have not been detected or quantified. Systemically, serum UA is a …

Background Hyperuricemia is associated with reduced survival among patients with heart
failure (HF), but the effect of gout on HF outcomes is unknown. A recent randomized trial …

In an effort to identify novel candidate regulators of adipogenesis, gene profiling of
differentiating 3T3-L1 preadipocytes was analyzed using a novel algorithm. We report here …