NK cell-based immunotherapy for malignant diseases

M Cheng, Y Chen, W Xiao, R Sun, Z Tian - Cellular & molecular …, 2013 - nature.com
Natural killer (NK) cells play critical roles in host immunity against cancer. In response,
cancers develop mechanisms to escape NK cell attack or induce defective NK cells. Current …

Inflammatory cells in diffuse large B cell lymphoma

R Tamma, G Ranieri, G Ingravallo, T Annese… - Journal of Clinical …, 2020 - mdpi.com
Diffuse large B cell lymphoma (DLBCL), known as the most common non-Hodgkin
lymphoma (NHL) subtype, is characterized by high clinical and biological heterogeneity. The …

HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells

Y Wang, L Lifshitz, K Gellatly, CL Vinton… - Nature …, 2020 - nature.com
Abstract Human immunodeficiency virus 1 (HIV-1) infection is associated with heightened
inflammation and excess risk of cardiovascular disease, cancer and other complications …

NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease

EL Azeredo, LM De Oliveira-Pinto… - Clinical & …, 2006 - academic.oup.com
During the innate immune response against infections, Natural Killer (NK) cells are as
important effector cells as are Cytotoxic T lymphocytes (CTL) generated after antigenic …

The advances and challenges of NK cell-based cancer immunotherapy

S Kang, X Gao, L Zhang, E Yang, Y Li, L Yu - Current Oncology, 2021 - mdpi.com
Natural killer (NK) cells can be widely applied for cancer immunotherapy due to their ability
to lyse tumor targets without prior sensitization or human leukocyte antigens-matching …

Targeting NK cells to enhance melanoma response to immunotherapies

H Lee, IP Da Silva, U Palendira, RA Scolyer, GV Long… - Cancers, 2021 - mdpi.com
Simple Summary NK cells are innate immune cells that form one of the initial responses to
infections and cancers. There have been increasing number of studies investigating the anti …

Human small-intestinal epithelium contains functional natural killer lymphocytes

F León, E Roldán, L Sanchez, C Camarero, A Bootello… - Gastroenterology, 2003 - Elsevier
BACKGROUND & AIMS:: CD3− non-T lymphocytes constitute the second most abundant
lymphoid subset in the human small-bowel epithelium, and these CD3− intraepithelial …

Synthesis and surface expression of hyaluronan by dendritic cells and its potential role in antigen presentation

ME Mummert, D Mummert, D Edelbaum… - The Journal of …, 2002 - journals.aai.org
Hyaluronan (HA) is a large glycosaminoglycan consisting of repeating disaccharide units of
glucuronic acid and N-acetylglucosamine. HA is known to act as a filling material of …

Signaling through CD38 induces NK cell activation

R Mallone, A Funaro, M Zubiaur, G Baj… - International …, 2001 - academic.oup.com
Human CD38 is a signal transduction molecule, and, concurrently, an ectoenzyme
catalyzing the synthesis and degradation of cyclic ADP-ribose (cADPR), a potent Ca2+ …

CD38 triggers cytotoxic responses in activated human natural killer cells

G Sconocchia, JA Titus, A Mazzoni… - Blood, The Journal …, 1999 - ashpublications.org
Receptors used by natural killer (NK) cells to mediate natural cytotoxicity are poorly defined,
although it is now clear that a number of adhesion molecules can serve this function. CD38 …