The current available therapeutics face several challenges such as the development of ideal
drug delivery systems towards the goal of personalized treatments for patients benefit. The …

Photocleavable biomaterials and bioconjugates are particularly interesting because light
sources are easy to obtain and the responsiveness of materials is convenient to control. In …

Background It has been hypothesized that heteromers of adenosine A 2A receptors (A2AR)
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …

New technologies for spatial and temporal remote control of G protein-coupled receptors
(GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and …

Several useful animal models for parkinsonism have been developed so far. Haloperidol‐
induced catalepsy is often used as a rodent model for the study of motor impairments …

The modulation of the A2B adenosine receptor is a promising strategy in cancer (immuno)
therapy, with A2BAR antagonists emerging as immune checkpoint inhibitors. Herein, we …

The discovery and clinical implementation of modulators of adenosine, P2Y and P2X
receptors (comprising nineteen subtypes) have progressed dramatically in∼ 50 years since …

Precise modulation of neuronal activity by neuroactive molecules is essential for
understanding brain circuits and behavior. However, tools for highly controllable molecular …

Photoactivatable drugs and peptides can drive quantitative studies into receptor signaling
with high spatiotemporal precision, yet few are compatible with behavioral studies in …

Background and Purpose Opioid‐based drugs are the gold standard medicines for pain
relief. However, tolerance and several side effects (ie constipation and dependence) may …