Experimental drugs in clinical trials for COPD: artificial intelligence via machine learning approach to predict the successful advance from early-stage development to …

L Calzetta, E Pistocchini, A Chetta… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Therapeutic advances in drug therapy of chronic obstructive pulmonary disease
(COPD) really effective in suppressing the pathological processes underlying the disease …

Contemporary concise review 2022: chronic obstructive pulmonary disease

PMA Calverley, PP Walker - Respirology, 2023 - Wiley Online Library
SUMMARY OF KEY POINTS International respiratory organizations now recommend using
lower limit of normal and standardized residuals to diagnose airflow obstruction and COPD …

[HTML][HTML] Chronic cough—the limitation and advances in assessment techniques

M Zhang, DL Sykes, K Brindle… - Journal of Thoracic …, 2022 - ncbi.nlm.nih.gov
Accurate and consistent assessments of cough are essential to advance the understanding
of the mechanisms of cough and individualised the management of patients. Considerable …

[HTML][HTML] Pathophysiology, therapeutic targets, and future therapeutic alternatives in COPD: Focus on the importance of the cholinergic system

F Gomes, SL Cheng - Biomolecules, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by
airway limitation and changes in airway structure. It has a high global burden of mortality …

[HTML][HTML] The future of inhalation therapy in chronic obstructive pulmonary disease

M Cazzola, J Ora, L Calzetta, P Rogliani… - Current Research in …, 2022 - Elsevier
The inhaled route is critical for the administration of drugs to treat patients suffering from
COPD, but there is still an unmet need for new and innovative inhalers to address some …

Advances in adrenergic receptors for the treatment of chronic obstructive pulmonary disease: 2023 update

MG Matera, B Rinaldi, L Calzetta… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Strong scientific evidence and large experience support the use of β2-agonists
for the symptomatic alleviation of COPD. Therefore, there is considerable effort in …

[HTML][HTML] Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease

T Wang, P Fu, F Long, S Liu, S Hu, Q Wang… - European Journal of …, 2023 - Springer
Objectives To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in
treating patients with chronic obstructive pulmonary disease (COPD). Methods Clinical data …

Navafenterol for chronic obstructive pulmonary disease therapy

SA Antoniu, CM Handra, A Rascu… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Chronic obstructive pulmonary disease (COPD) is a prevalent disease of the
airways in which inhaled bronchodilators can be given as monotherapy or fixed dose …

一种治疗慢性阻塞性气道疾病的新药: 那伐芬特罗

刘育如, 吴雯雯, 王刚 - 中国临床药理学与治疗学, 2024 - manu41.magtech.com.cn
那伐芬特罗(navafenterol) 是一单分子且同时具备毒蕈碱受体拮抗和β2 受体激动效应的新型
化合物, 正开发用于治疗慢性阻塞性肺疾病和哮喘等慢性阻塞气道疾病. 该药可显著改善肺功能 …

Navafenterol, a new drug for the treatment of chronic obstructive airway disease

Y LIU, W WU, G WANG - Chinese Journal of Clinical …, 2024 - manu41.magtech.com.cn
Navafenterol is a new compound with both muscarinic receptor antagonist and β2 receptor
agonist effects in a single molecule, who is being developed for the treatment of chronic …