The introduction of the E Factor in 1992 focussed attention on the problem of waste
generation, defined as everything but the desired product, in chemicals manufacture and …

Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

The role and power of biocatalysis in sustainable chemistry has been continuously brought
forward step by step to its present outstanding position. The problem‐solving capabilities of …

Biocatalysis is an established chemical synthesis technology that has by no means been
restricted to research laboratories. The use of enzymes for organic synthesis has evolved …

HIV reverse transcriptase (RT) inhibitors are the important components of highly active
antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in …

As a crucial factor of their therapeutic efficacy, the currently marketed mRNA vaccines
feature uniform substitution of uridine (U) by the corresponding C-nucleoside, pseudouridine …

Pyrazolopyrimidine scaffold is one of the privileged heterocycles in drug discovery. This
scaffold produced numerous biological activities in which anticancer is important one …

Highlights•Newly discovered enzymes possessing C-nucleoside synthase activity for
biocatalysis.•Multistep cascade reactions involving up to nine enzymes.•One-pot synthesis …

Introduction Nucleoside analogues represent a cornerstone of achievement in drug
discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery …

Catalysis with engineered enzymes has provided more efficient routes for the production of
active pharmaceutical agents. However, the potential of biocatalysis to assist in early-stage …