[HTML][HTML] Programmed death of cardiomyocytes in cardiovascular disease and new therapeutic approaches

K Cai, H Jiang, Y Zou, C Song, K Cao, S Chen… - Pharmacological …, 2024 - Elsevier
Cardiovascular diseases (CVDs) have a complex pathogenesis and pose a major threat to
human health. Cardiomyocytes have a low regenerative capacity, and their death is a key …

hUC-MSC-EV-miR-24 enhances the protective effect of dexmedetomidine preconditioning against myocardial ischemia–reperfusion injury through the KEAP1/Nrf2 …

Z Hou, F Yang, K Chen, Y Wang, J Qin… - Drug Delivery and …, 2024 - Springer
The cardioprotective effect of microRNAs (miRNAs) on myocardial ischemic-reperfusion (I/R)
injury has been documented. Here, we aim to decipher the mechanism of miR-24 delivered …

Riboflavin protects against heart failure via SCAD‐dependent DJ‐1–Keap1–Nrf2 signalling pathway

Q Xu, Y Cao, X Zhong, X Qin, J Feng… - British journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose Our recent studies have shown that flavin adenine
dinucleotide (FAD) exerts cardiovascular protective effects by supplementing short‐chain …

miR-129-5p restores cardiac function in rats with chronic heart failure by targeting the E3 ubiquitin ligase Smurf1 and promoting PTEN expression

Y Qi, Y Tang, L Yin, K Ding, C Zhao, W Yan… - Bioengineered, 2022 - Taylor & Francis
Chronic heart failure (CHF) is a prevalent health concern with complex pathogenesis. This
current study set out to estimate the function of the miR-129-5p/Smurf1/PTEN axis on cardiac …

Dexmedetomidine prevents cardiomyocytes from hypoxia/reoxygenation injury via modulating tetmethylcytosine dioxygenase 1-mediated DNA demethylation of …

L Wang, S Wang, T Jia, X Sun, Z Xing, H Liu, J Yao… - …, 2022 - Taylor & Francis
Myocardial hypoxia/reoxygenation (H/R) injury is a common pathological change in patients
with acute myocardial infarction undergoing reperfusion therapy. Dexmedetomidine (DEX) …

Transcriptome sequencing and lncRNA-miRNA-mRNA network construction in cardiac fibrosis and heart failure

S Wang, T Lv, Q Chen, Y Yang, L Xu, X Zhang… - …, 2022 - Taylor & Francis
Cardiac fibrosis (CF) and heart failure (HF) are common heart diseases, and severe CF can
lead to HF. In this study, we tried to find their common potential molecular markers, which …

RETRACTED ARTICLE: Mirtazapine prevents cell activation, inflammation, and oxidative stress against isoflurane exposure in microglia

Q Wang, M Ma, H Yu, H Yu, S Zhang, R Li - Bioengineered, 2022 - Taylor & Francis
Statement of Retraction Qi Wnag, Meina Ma, Hong Yu, Hongmei Yu, Shuai Zhan, Rui Li-
2022, Mirtazapine prevents cell activation, inflammation, and oxidative stress against …

The Berberis vulgaris L. extract berberine exerts its anti-oxidant effects to ameliorate cholesterol overloading–induced cell apoptosis in the primary mice hepatocytes …

Z Ye, Q Wang, S Dai, X Ji, P Cao, C Xu… - In Vitro Cellular & …, 2022 - Springer
Cholesterol overloading stress damages normal cellular functions in hepatocytes and
induces metabolic disorders to facilitate the development of multiple diseases, including …

Long non-coding RNA AK006774 inhibits cardiac ischemia-reperfusion injury via sponging miR-448

S Nie, X Cui, J Guo, X Ma, H Zhi, S Li, Y Li - Bioengineered, 2021 - Taylor & Francis
In recent years, the incidence and mortality of myocardial infarction (MI) have been
increasing throughout the world, threatening public health. Non-coding RNAs (ncRNAs) …

XinLi formula, a traditional Chinese decoction, alleviates chronic heart failure via regulating the interaction of AGTR1 and AQP1

XH Wei, WJ Liu, W Jiang, TH Lan, MY Ma, LZ You… - Phytomedicine, 2023 - Elsevier
Background XinLi formula (XLF) is a traditional Chinese medicine used in clinical practice to
treat chronic heart failure (CHF) in humans, with remarkable curative effect. However, the …