The role of glutathione peroxidase-1 in health and disease

DE Handy, J Loscalzo - Free Radical Biology and Medicine, 2022 - Elsevier
Abstract Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …

Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls

M Heidarzadeh, Y Gürsoy-Özdemir, M Kaya… - Cell & Bioscience, 2021 - Springer
Nowadays, a large population around the world, especially the elderly, suffers from
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …

Cancer-associated venous thromboembolism: burden, mechanisms, and management

C Ay, I Pabinger, AT Cohen - Thrombosis and haemostasis, 2017 - thieme-connect.com
Venous thromboembolism (VTE) is a significant health problem in the general population
but especially in cancer patients. In this review, we discuss the epidemiology and burden of …

Platelets and extracellular vesicles and their cross talk with cancer

S Lazar, LE Goldfinger - Blood, The Journal of the American …, 2021 - ashpublications.org
Platelets play significant and varied roles in cancer progression, as detailed throughout this
review series, via direct interactions with cancer cells and by long-range indirect interactions …

Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents

XR Xu, GM Yousef, H Ni - Blood, The Journal of the American …, 2018 - ashpublications.org
Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …

Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

XR Xu, D Zhang, BE Oswald, N Carrim… - Critical reviews in …, 2016 - Taylor & Francis
Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Platelet TLR4-ERK5 axis facilitates NET-mediated capturing of circulating tumor cells and distant metastasis after surgical stress

J Ren, J He, H Zhang, Y Xia, Z Hu, P Loughran, T Billiar… - Cancer research, 2021 - AACR
Surgical removal of malignant tumors is a mainstay in controlling most solid cancers.
However, surgical insult also increases the risk of tumor recurrence and metastasis. Tissue …

Vascular endothelial growth factor signaling in hypoxia and inflammation

S Ramakrishnan, V Anand, S Roy - Journal of neuroimmune …, 2014 - Springer
Infection, cancer and cardiovascular diseases are the major causes for morbidity and
mortality in the United States according to the Center for Disease Control. The underlying …

Cancer-associated thrombosis: an overview

G Elyamany, AM Alzahrani… - Clinical Medicine …, 2014 - journals.sagepub.com
Venous thromboembolism (VTE) is a common complication in patients with malignant
disease. Emerging data have enhanced our understanding of cancer-associated …

Apolipoprotein A-IV: a multifunctional protein involved in protection against atherosclerosis and diabetes

J Qu, CW Ko, P Tso, A Bhargava - Cells, 2019 - mdpi.com
Apolipoprotein A-IV (apoA-IV) is a lipid-binding protein, which is primarily synthesized in the
small intestine, packaged into chylomicrons, and secreted into intestinal lymph during fat …