The role of glutathione peroxidase-1 in health and disease
DE Handy, J Loscalzo - Free Radical Biology and Medicine, 2022 - Elsevier
Abstract Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …
Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls
M Heidarzadeh, Y Gürsoy-Özdemir, M Kaya… - Cell & Bioscience, 2021 - Springer
Nowadays, a large population around the world, especially the elderly, suffers from
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …
Cancer-associated venous thromboembolism: burden, mechanisms, and management
Venous thromboembolism (VTE) is a significant health problem in the general population
but especially in cancer patients. In this review, we discuss the epidemiology and burden of …
but especially in cancer patients. In this review, we discuss the epidemiology and burden of …
Platelets and extracellular vesicles and their cross talk with cancer
S Lazar, LE Goldfinger - Blood, The Journal of the American …, 2021 - ashpublications.org
Platelets play significant and varied roles in cancer progression, as detailed throughout this
review series, via direct interactions with cancer cells and by long-range indirect interactions …
review series, via direct interactions with cancer cells and by long-range indirect interactions …
Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents
Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …
however, growing evidence suggests that they are also significantly involved in cancer, the …
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond
Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
Platelet TLR4-ERK5 axis facilitates NET-mediated capturing of circulating tumor cells and distant metastasis after surgical stress
Surgical removal of malignant tumors is a mainstay in controlling most solid cancers.
However, surgical insult also increases the risk of tumor recurrence and metastasis. Tissue …
However, surgical insult also increases the risk of tumor recurrence and metastasis. Tissue …
Vascular endothelial growth factor signaling in hypoxia and inflammation
Infection, cancer and cardiovascular diseases are the major causes for morbidity and
mortality in the United States according to the Center for Disease Control. The underlying …
mortality in the United States according to the Center for Disease Control. The underlying …
Cancer-associated thrombosis: an overview
G Elyamany, AM Alzahrani… - Clinical Medicine …, 2014 - journals.sagepub.com
Venous thromboembolism (VTE) is a common complication in patients with malignant
disease. Emerging data have enhanced our understanding of cancer-associated …
disease. Emerging data have enhanced our understanding of cancer-associated …
Apolipoprotein A-IV: a multifunctional protein involved in protection against atherosclerosis and diabetes
Apolipoprotein A-IV (apoA-IV) is a lipid-binding protein, which is primarily synthesized in the
small intestine, packaged into chylomicrons, and secreted into intestinal lymph during fat …
small intestine, packaged into chylomicrons, and secreted into intestinal lymph during fat …