Stealth nanoparticles in oncology: Facing the PEG dilemma

S Zalba, TLM Ten Hagen, C Burgui… - Journal of Controlled …, 2022 - Elsevier
Nanoparticles (Nps) have revolutionized the landscape of many treatments, by modifying not
only pharmacokinetic properties of the encapsulated agent, but also providing a significant …

Surface modification strategies in translocating nano-vesicles across different barriers and the role of bio-vesicles in improving anticancer therapy

P Tiwari, K Yadav, RP Shukla, S Gautam… - Journal of Controlled …, 2023 - Elsevier
Nanovesicles and bio-vesicles (BVs) have emerged as promising tools to achieve targeted
cancer therapy due to their ability to overcome many of the key challenges currently being …

The pro-tumorigenic host response to cancer therapies

Y Shaked - Nature Reviews Cancer, 2019 - nature.com
Resistance to cancer therapy remains a major challenge in clinical oncology. Although the
initial treatment phase is often successful, eventual resistance, characterized by tumour …

Cell membrane-camouflaged nanoparticles as drug carriers for cancer therapy

CH Xu, PJ Ye, YC Zhou, DX He, H Wei, CY Yu - Acta biomaterialia, 2020 - Elsevier
The translocation of natural cell membranes to the surface of synthetic nanoparticles, which
allows man-made vectors to share merits and functionalities created by nature, has been a …

[HTML][HTML] The double edge sword of fibrosis in cancer

C Chandler, T Liu, R Buckanovich, LG Coffman - Translational Research, 2019 - Elsevier
Cancer-associated fibrosis is a critical component of the tumor microenvironment (TME)
which significantly impacts cancer behavior. However, there is significant controversy …

Identifying the therapeutic significance of mesenchymal stem cells

VK Mishra, HH Shih, F Parveen, D Lenzen, E Ito… - Cells, 2020 - mdpi.com
The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due
to their immense potential for immunosuppression and their therapeutic role in immune …

Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance

X Xuan, C Tian, M Zhao, Y Sun, C Huang - Cancer cell international, 2021 - Springer
Increasing evidence indicates that the tumor microenvironment appears to play an
increasingly important role in cancer progression and therapeutic resistance. Several types …

Tumour cell secretome in chemoresistance and tumour recurrence

EC Madden, AM Gorman, SE Logue, A Samali - Trends in cancer, 2020 - cell.com
Chemoresistance is a major factor driving tumour relapse and the high rates of cancer-
related deaths. Understanding how cancer cells overcome chemotherapy-induced cell …

The multifaceted role of mesenchymal stem cells in cancer

M Timaner, KK Tsai, Y Shaked - Seminars in cancer biology, 2020 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that
give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes …

Stem cell–nanomedicine system as a theranostic bio-gadolinium agent for targeted neutron capture cancer therapy

YH Lai, CY Su, HW Cheng, CY Chu, LB Jeng… - Nature …, 2023 - nature.com
The potential clinical application of gadolinium-neutron capture therapy (Gd-NCT) for
glioblastoma multiforme (GBM) treatment has been compromised by the fast clearance and …