In all organisms, cell proliferation is orchestrated by coordinated patterns of gene
expression. Transcription results from the activity of the RNA polymerase machinery and …

The cancer epigenome is characterised by specific DNA methylation and chromatin
modification patterns. The proteins that mediate these changes are encoded by the …

Acute myeloid leukemia (AML) with translocation t (8; 16)(p11; p13) is an infrequent
leukemia subtype with characteristic clinicobiological features. This translocation leads to …

Balanced chromosomal rearrangements define distinct entities in acute myeloid leukemia
(AML). Here, we present 13 AML cases with t (8; 16)(p11; p13) with observed low incidence …

Abstract The t (8; 16)(p11; p13) fuses the MOZ (MYST3) gene at 8p11 with CBP (CREBBP)
at 16p13 and is associated with an infrequent but well‐defined type of acute myeloid …

Previous small series have suggested that acute myeloid leukemia with t (8; 16) is a distinct
morphologic and clinical entity associated with poor prognosis. We describe 18 patients with …

MOZ (monocytic leukaemia zinc finger protein; also known as ZNF220 or MYST3) is a
member of the MYST family of protein acetyltransferases. Chromosomal translocations …

Juvenile myelomonocytic leukaemia (JMML) is a unique myeloproliferative disorder of early
childhood. Frequently, mutations in NRAS, KRAS, PTPN11, NF1 or CBL are found in these …

Abstract The translocation t (8; 16)(p11; p13) is associated with acute myeloid leukemia
displaying monocytic differentiation (AML FAB M4/5) and fuses the MOZ (also named …

During the past few decades, it has become increasingly apparent that heredity is not the
sole determining factor in disease development, such as cancer. This landmark work covers …