[HTML][HTML] Interleukins 4 and 13 in asthma: key pathophysiologic cytokines and druggable molecular targets
Interleukins (IL)-4 and-13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-
4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and …
4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and …
Melatonin in food allergy: Mechanism and potential therapy
H Wang, Y Yan, I Hung, C Liu, J Yin… - Journal of Pineal …, 2023 - Wiley Online Library
Food allergy affects more than 500 million people in the world, and its prevalence is
increasing at an alarming rate causing serious public health concerns; however, prevention …
increasing at an alarming rate causing serious public health concerns; however, prevention …
Pathobiology of type 2 inflammation in asthma and nasal polyposis
C Pelaia, G Pelaia, A Maglio, C Tinello… - Journal of clinical …, 2023 - mdpi.com
Asthma and nasal polyposis often coexist and are frequently intertwined by tight pathogenic
links, mainly consisting of the cellular and molecular pathways underpinning type 2 airway …
links, mainly consisting of the cellular and molecular pathways underpinning type 2 airway …
Microbial dysbiosis tunes the immune response towards allergic disease outcomes
The hygiene hypothesis has been popularized as an explanation for the rapid increase in
allergic disease observed over the past 50 years. Subsequent epidemiological studies have …
allergic disease observed over the past 50 years. Subsequent epidemiological studies have …
Pharmaceutical targeting Th2-mediated immunity enhances immunotherapy response in breast cancer
Y Chen, J Sun, Y Luo, J Liu, X Wang, R Feng… - Journal of translational …, 2022 - Springer
Background Breast cancer is a complex disease with a highly immunosuppressive tumor
microenvironment, and has limited clinical response to immune checkpoint blockade (ICB) …
microenvironment, and has limited clinical response to immune checkpoint blockade (ICB) …
Immunomodulatory properties of mesenchymal stem cells: A potential therapeutic strategy for allergic rhinitis
M Wang, N Zhao, C Wang, ZB Jin, L Zhang - Allergy, 2023 - Wiley Online Library
Allergic rhinitis is a highly prevalent chronic inflammatory disorder of the nasal mucosa that
poses a significant burden on patients' health and quality of life. Current therapies for …
poses a significant burden on patients' health and quality of life. Current therapies for …
Siglecs in allergy and asthma
BS Bochner, JA O'Sullivan, AT Chang… - Molecular aspects of …, 2023 - Elsevier
The term “allergic diseases” encompasses several common, IgE-mediated conditions that
range from being annoying to those that are life-threatening. Available treatments include …
range from being annoying to those that are life-threatening. Available treatments include …
Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway
Q Han, X Gao, S Wang, Z Wei, Y Wang, K Xu, M Chen - Toxicology Letters, 2023 - Elsevier
Increasing attention has been paid to the potential impact of microplastics (MPs) pollution on
human health. MPs and phthalates coexist in the environment, however, the effects of …
human health. MPs and phthalates coexist in the environment, however, the effects of …
Emerging insights into the impact of air pollution on immune-mediated asthma pathogenesis
JA Tuazon, B Kilburg-Basnyat, LM Oldfield… - Current allergy and …, 2022 - Springer
Abstract Purpose of Review Increases in ambient levels of air pollutants have been linked to
lung inflammation and remodeling, processes that lead to the development and …
lung inflammation and remodeling, processes that lead to the development and …
Epigallocatechin gallate relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages
N Yang, X Li - Biochemical Pharmacology, 2022 - Elsevier
Epigallocatechin gallate (EGCG) is an active catechin in green tea and has multiple
biological functions, such as anti-inflammation, anti-cancer, and immune regulation. This …
biological functions, such as anti-inflammation, anti-cancer, and immune regulation. This …