[HTML][HTML] Epithelial barrier theory: the role of exposome, microbiome, and barrier function in allergic diseases

P Losol, M Sokolowska, YK Hwang… - Allergy, asthma & …, 2023 - ncbi.nlm.nih.gov
Allergic diseases are a major public health problem with increasing prevalence. These
immune-mediated diseases are characterized by defective epithelial barriers, which are …

[HTML][HTML] Regulatory ILC2—Role of IL-10 Producing ILC2 in Asthma

N Emami Fard, M Xiao, R Sehmi - Cells, 2023 - mdpi.com
Over the past two decades, a growing body of evidence observations have shown group two
innate lymphoid cells (ILC2) to be critical drivers of Type 2 (T2) inflammatory responses …

Interactions between calcium regulatory pathways and mechanosensitive channels in airways

Y Yao, NA Borkar, M Zheng, S Wang… - Expert Review of …, 2023 - Taylor & Francis
Introduction Asthma is a chronic lung disease influenced by environmental and inflammatory
triggers and involving complex signaling pathways across resident airway cells such as …

[HTML][HTML] Transcriptomic analysis identified SLC40A1 as a key iron metabolism-related gene in airway macrophages in childhood allergic asthma

Z Wang, Y He, Y Cun, Q Li, Y Zhao… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: Asthma is the most common chronic condition in children, with allergic asthma
being the most common phenotype, accounting for approximately 80% of cases. Growing …

Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases

J Liu, S Liu, M Yu, J Li, Z Xie, B Gao… - Drug Development …, 2023 - Wiley Online Library
Catalpol is a kind of iridoid glucoside, widely found in a variety of plants, mostly extracted
from the rhizome of the traditional medicinal herb rehmanniae. It has various biological …

[HTML][HTML] Asthma and COVID-19: a controversial relationship

CA Dounce-Cuevas, A Flores-Flores, MS Bazán… - Virology Journal, 2023 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection induces a
spectrum of clinical manifestations that depend on the immune response of the patient, ie …

Exploring the therapeutic potential of monoclonal antibodies targeting TSLP and IgE in asthma management

S Yan, B Yang, H Qin, C Du, H Liu, T Jin - Inflammation Research, 2024 - Springer
Background In recent years, there has been a growing interest in the utilization of biologic
therapies for the management of asthma. Both TSLP and IgE are important immune …

[HTML][HTML] Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

MH Kim, CS Bae, SH Bok, HS Choi, T Ahn… - International Journal of …, 2023 - mdpi.com
Asthma is a chronic inflammatory disease of the pulmonary system associated with many
wheeze-to-sleep apnea complications that may lead to death. In 2019, approximately 262 …

Dysfunctional mucociliary clearance in asthma and airway remodeling–New insights into an old topic

M Jesenak, P Durdik, D Oppova, S Franova… - Respiratory …, 2023 - Elsevier
Bronchial asthma is a heterogeneous respiratory condition characterized by chronic airway
inflammation, airway hyperresponsiveness and airway structural changes (known as …

[HTML][HTML] Ιnterleukin-17A-enriched neutrophil extracellular traps promote immunofibrotic aspects of childhood asthma exacerbation

M Ntinopoulou, D Cassimos, E Roupakia, E Kolettas… - Biomedicines, 2023 - mdpi.com
Childhood asthma is a chronic inflammatory airway disorder that can drive tissue
remodeling. Neutrophils are amongst the most prominent inflammatory cells contributing to …