Chalcone-derivative L6H21 attenuates the OVA-induced asthma by targeting MD2
X Ge, T Xu, M Wang, L Gao, Y Tang, N Zhang… - European Journal of …, 2024 - Springer
Asthma represents a significant global challenge that affects individuals across all age
groups and imposes substantial social and economic burden. Due to heterogeneity of the …
groups and imposes substantial social and economic burden. Due to heterogeneity of the …
Role and Molecular Mechanisms of Alternative Splicing of Th2-Cytokines IL-4 and IL-5 in Atopic Bronchial Asthma
IP Shilovskiy, VI Kovchina, ED Timotievich… - Biochemistry …, 2023 - Springer
Bronchial asthma (BA) is a heterogeneous chronic inflammatory disease of the respiratory
tract. Allergic (atopic) asthma is the most common (up to 80% of cases) phenotype …
tract. Allergic (atopic) asthma is the most common (up to 80% of cases) phenotype …
Fecal Microbiota Transplantation Alleviates Allergic Rhinitis via CD4+ T Cell Modulation Through Gut Microbiota Restoration
L Dong, Y Tang, S Wen, Y He, F Li, Y Deng, Z Tao - Inflammation, 2024 - Springer
Allergic rhinitis (AR) is an allergic condition of the upper respiratory tract with a complex
pathogenesis, including epithelial barrier disruption, immune regulation, and gut microbiota …
pathogenesis, including epithelial barrier disruption, immune regulation, and gut microbiota …
Gene Polymorphisms of NLRP3 Associated With Plasma Levels of 4β‐Hydroxycholesterol, an Endogenous Marker of CYP3A Activity, in Patients With Asthma
K Hirai, T Kimura, Y Suzuki… - Clinical …, 2024 - Wiley Online Library
Inflammation decreases the activity of cytochrome P450 3A (CYP3A). Nucleotide‐binding
oligomerization domain (NOD)‐like receptor family pyrin domain containing 3 (NLRP3) is …
oligomerization domain (NOD)‐like receptor family pyrin domain containing 3 (NLRP3) is …
Increased expression of CSF1 in patients with eosinophilic asthma
L Du, L Tang, L Xiao, K Tang, Z Zeng… - Immunity …, 2023 - Wiley Online Library
Background The link between colony‐stimulating factor 1 (CSF1) and asthma was reported
recently. However, the role and mechanism of CSF1 in asthma remain poorly understood. In …
recently. However, the role and mechanism of CSF1 in asthma remain poorly understood. In …
[HTML][HTML] Single-Domain Antibodies—Novel Tools to Study and Treat Allergies
I Zettl, C Bauernfeind, J Kollárová, S Flicker - International Journal of …, 2024 - mdpi.com
IgE-mediated allergies represent a major health problem in the modern world. Apart from
allergen-specific immunotherapy (AIT), the only disease-modifying treatment, researchers …
allergen-specific immunotherapy (AIT), the only disease-modifying treatment, researchers …
Network analyses of upper and lower airway transcriptomes identify shared mechanisms among children with recurrent wheezing and school-age asthma
Z Wang, Y He, Q Li, Y Zhao, G Zhang… - Frontiers in Immunology, 2023 - frontiersin.org
Background Predicting which preschool children with recurrent wheezing (RW) will develop
school-age asthma (SA) is difficult, highlighting the critical need to clarify the pathogenesis …
school-age asthma (SA) is difficult, highlighting the critical need to clarify the pathogenesis …
Bacterial antigens and asthma: a comparative study of common respiratory pathogenic bacteria
J Pang, Y Shi, D Peng, L Cui, Y Xu, W Wang… - Journal of …, 2024 - Taylor & Francis
Objective: In a previous study we have shown that, in the presence of interleukin (IL)-33,
repeated, per-nasal challenge of murine airways with Streptococcus pneumoniae (S …
repeated, per-nasal challenge of murine airways with Streptococcus pneumoniae (S …
Linkage of serum ITIH4 with Th2 signature cytokine, inflammation, exacerbation risk and severity in childhood asthma
W Li, X Wang, H An - Biomarkers in Medicine, 2024 - Taylor & Francis
Aim: ITIH4 has anti-inflammatory properties toward eosinophilic/neutrophilic inflammation.
This study aimed to explore clinical value of ITIH4 in childhood asthma. Materials & …
This study aimed to explore clinical value of ITIH4 in childhood asthma. Materials & …
Anti-CD20 treatment attenuates Th2 cell responses: implications for the role of lung follicular mature B cells in the asthmatic mice
J He, J Li, Q Lin, H Ni, S Huang, H Cheng, X Ding… - Inflammation …, 2024 - Springer
Background B cells were believed to act as antigen-presenting cells (APCs) to promote T
helper type 2 (Th2) cell responses. However, the role of lung B cells and its subpopulations …
helper type 2 (Th2) cell responses. However, the role of lung B cells and its subpopulations …