[HTML][HTML] Control of human toxoplasmosis
Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …
The flexibility of Apicomplexa parasites in lipid metabolism
Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …
CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells
Toxoplasma virulence depends on its ability to evade or survive the toxoplasmacidal
mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved …
mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved …
[PDF][PDF] A Plasmodium falciparum lysophospholipase regulates host fatty acid flux via parasite lipid storage to enable controlled asexual schizogony
Phospholipid metabolism is crucial for membrane biogenesis and homeostasis of
Plasmodium falciparum. To generate such phospholipids, the parasite extensively …
Plasmodium falciparum. To generate such phospholipids, the parasite extensively …
An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum
M Asad, Y Yamaryo-Botté, ME Hossain, V Thakur… - BMC biology, 2021 - Springer
Background Plasmodium falciparum is the pathogen responsible for the most devastating
form of human malaria. As it replicates asexually in the erythrocytes of its human host, the …
form of human malaria. As it replicates asexually in the erythrocytes of its human host, the …
Toxoplasma metabolic flexibility in different growth conditions
Apicomplexan parasites have complex metabolic networks that coordinate acquisition of
metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has …
metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has …
Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability
EA Renaud, S Pamukcu, A Cerutti, L Berry… - Journal of Biological …, 2022 - ASBMB
Like many other apicomplexan parasites, Toxoplasma gondii contains a plastid harboring
key metabolic pathways, including the sulfur utilization factor (SUF) pathway that is involved …
key metabolic pathways, including the sulfur utilization factor (SUF) pathway that is involved …
The Extracellular Milieu of Toxoplasma's Lytic Cycle Drives Lab Adaptation, Primarily by Transcriptional Reprogramming
Evolve and resequencing (E&R) was applied to lab adaptation of Toxoplasma gondii for
over 1,500 generations with the goal of mapping host-independent in vitro virulence traits …
over 1,500 generations with the goal of mapping host-independent in vitro virulence traits …
[HTML][HTML] Toxoplasma gondii's basal complex: the other apicomplexan business end is multifunctional
MJ Gubbels, DJP Ferguson, S Saha… - Frontiers in Cellular …, 2022 - frontiersin.org
The Apicomplexa are famously named for their apical complex, a constellation of organelles
at their apical end dedicated to invasion of their host cells. In contrast, at the other end of the …
at their apical end dedicated to invasion of their host cells. In contrast, at the other end of the …
Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
Apicomplexa are obligate intracellular parasites responsible for major human diseases.
Their intracellular survival relies on intense lipid synthesis, which fuels membrane …
Their intracellular survival relies on intense lipid synthesis, which fuels membrane …