TERT promoter mutations in cancer development
B Heidenreich, PS Rachakonda, K Hemminki… - Current opinion in …, 2014 - Elsevier
Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of
telomerase that maintains genomic integrity. TERT expression is mostly repressed in …
telomerase that maintains genomic integrity. TERT expression is mostly repressed in …
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …
Integrated mutational landscape analysis of uterine leiomyosarcomas
Uterine leiomyosarcomas (uLMS) are aggressive tumors arising from the smooth muscle
layer of the uterus. We analyzed 83 uLMS sample genetics, including 56 from Yale and 27 …
layer of the uterus. We analyzed 83 uLMS sample genetics, including 56 from Yale and 27 …
The evolving (epi) genetic landscape of pancreatic neuroendocrine tumours
CP Pipinikas, AM Berner, T Sposito… - Endocrine-related …, 2019 - erc.bioscientifica.com
Neuroendocrine neoplasms (NENs) are a relatively rare group of heterogeneous tumours
originating from neuroendocrine cells found throughout the body. Pancreatic NENs …
originating from neuroendocrine cells found throughout the body. Pancreatic NENs …
Genetic aspects of pituitary adenomas
P Marques, M Korbonits - Endocrinology and Metabolism …, 2017 - endo.theclinics.com
Pituitary adenomas (PAs) are common monoclonal tumors arising from adenohypophysis
cells. 1 PAs account for 15% of all intracranial tumors, being the third most common type of …
cells. 1 PAs account for 15% of all intracranial tumors, being the third most common type of …
Hereditary hyperparathyroidism syndromes
F Giusti, L Cavalli, T Cavalli, ML Brandi - Journal of Clinical Densitometry, 2013 - Elsevier
Primary hyperparathyroidism is a common endocrine disorder, resulting from a persistent
hypercalcemia along with an inadequate secretion of parathyroid hormone. In approx 95 …
hypercalcemia along with an inadequate secretion of parathyroid hormone. In approx 95 …
Human telomerase expression regulation
M Gladych, A Wojtyla, B Rubis - Biochemistry and cell biology, 2011 - cdnsciencepub.com
Since telomerase has been recognized as a relevant factor distinguishing cancer cells from
normal cells, it has become a very promising target for anti-cancer therapy. A correlation …
normal cells, it has become a very promising target for anti-cancer therapy. A correlation …
Menin coordinates C/EBPβ-mediated TGF-β signaling for epithelial-mesenchymal transition and growth inhibition in pancreatic cancer
P Cheng, Y Chen, T He, C Wang, S Guo, H Hu… - … Therapy-Nucleic Acids, 2019 - cell.com
Menin displays either tumor suppression or promotion functions in a context-dependent
manner. Previously, we proposed that Menin acts as a tumor suppressor by inhibiting cell …
manner. Previously, we proposed that Menin acts as a tumor suppressor by inhibiting cell …
miR-762 can negatively regulate menin in ovarian cancer
R Hou, Z Yang, SZ Wang, DM Chu, Q Liu… - OncoTargets and …, 2017 - Taylor & Francis
Ovarian cancer accounts for the major part of the mortality attributable to female reproductive
system malignant tumors worldwide. Recently, the incidence of ovarian cancer has been …
system malignant tumors worldwide. Recently, the incidence of ovarian cancer has been …
[HTML][HTML] Functional dissection of breast cancer risk-associated TERT promoter variants
S Helbig, L Wockner, A Bouendeu, U Hille-Betz… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The multi-cancer susceptibility locus at 5p15. 33 includes TERT, encoding the telomerase
catalytic subunit. Genome-wide association studies (GWAS) have identified six single …
catalytic subunit. Genome-wide association studies (GWAS) have identified six single …