Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of
telomerase that maintains genomic integrity. TERT expression is mostly repressed in …

Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …

Uterine leiomyosarcomas (uLMS) are aggressive tumors arising from the smooth muscle
layer of the uterus. We analyzed 83 uLMS sample genetics, including 56 from Yale and 27 …

Neuroendocrine neoplasms (NENs) are a relatively rare group of heterogeneous tumours
originating from neuroendocrine cells found throughout the body. Pancreatic NENs …

Pituitary adenomas (PAs) are common monoclonal tumors arising from adenohypophysis
cells. 1 PAs account for 15% of all intracranial tumors, being the third most common type of …

Primary hyperparathyroidism is a common endocrine disorder, resulting from a persistent
hypercalcemia along with an inadequate secretion of parathyroid hormone. In approx 95 …

Since telomerase has been recognized as a relevant factor distinguishing cancer cells from
normal cells, it has become a very promising target for anti-cancer therapy. A correlation …

Menin displays either tumor suppression or promotion functions in a context-dependent
manner. Previously, we proposed that Menin acts as a tumor suppressor by inhibiting cell …

Ovarian cancer accounts for the major part of the mortality attributable to female reproductive
system malignant tumors worldwide. Recently, the incidence of ovarian cancer has been …

The multi-cancer susceptibility locus at 5p15. 33 includes TERT, encoding the telomerase
catalytic subunit. Genome-wide association studies (GWAS) have identified six single …