[HTML][HTML] Restoring the oxidative balance in age-related diseases–An approach in glaucoma

PR Cáceres-Vélez, F Hui, J Hercus, B Bui… - Ageing Research …, 2022 - Elsevier
As human life expectancy increases, age-related health issues including neurodegenerative
diseases continue to rise. Regardless of genetic or environmental factors, many …

Gene therapies and gene product-based drug candidates for normalizing and preserving tissue functions in animal models of ocular hypertension and glaucoma

NA Sharif - Molecular Aspects of Medicine, 2023 - Elsevier
More than 76 million people worldwide are afflicted with the neurodegenerative eye
diseases described and grouped together as glaucoma. A common feature amongst the …

A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma

SS Verma, HV Gudiseva, VRM Chavali, RJ Salowe… - Cell, 2024 - cell.com
Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness
worldwide, disproportionately affects individuals of African ancestry. We conducted a …

Elevated intraocular pressure and glaucomatous optic neuropathy: genes to disease mechanisms, therapeutic drugs, and gene therapies

NA Sharif - Pharmaceuticals, 2023 - mdpi.com
This review article focuses on the pathogenesis of and genetic defects linked with chronic
ocular hypertension (cOHT) and glaucoma. The latter ocular disease constitutes a group of …

Beyond the optic nerve: Genetics, diagnosis, and promising therapies for glaucoma

M Kaushik, P Tiwari, T Dada, R Dada - Gene, 2023 - Elsevier
Glaucoma stands as a leading global cause of blindness, affecting millions. It entails optic
nerve damage and vision loss, categorized into open-angle and closed-angle glaucoma …

Molecular genetics of inherited normal tension glaucoma

Y Pan, T Iwata - Indian Journal of Ophthalmology, 2024 - journals.lww.com
Normal tension glaucoma (NTG) is a complex optic neuropathy characterized by
progressive retinal ganglion cell death and glaucomatous visual field loss, despite normal …

Molecular genetics of primary open-angle glaucoma

M Yadav, A Bhardwaj, A Yadav, R Dada… - Indian Journal of …, 2023 - journals.lww.com
Glaucoma is a series of linked optic diseases resulting in progressive vision loss and total
blindness due to the acquired loss of retinal ganglion cells. This harm to the optic nerve …

A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels

FE Gomes, MI Casanova, L Mouttham… - American Journal of …, 2022 - Am Vet Med Assoc
OBJECTIVE To identify genetic associations with primary glaucoma (PG) in American
Cocker Spaniels using a genome-wide association study (GWAS). ANIMALS A nationwide …

Cardiac Surgery Patients Have Reduced Vascularity and Structural Defects of the Retina Similar to Persons with Open-Angle Glaucoma

G Vičaitė, L Barišauskaitė, V Bakstytė, B Siesky… - Diagnostics, 2024 - mdpi.com
(1) Background: Growing evidence suggests impairment of ocular blood flow in open-angle
glaucoma (OAG) pathology, but little is known about the effect of an impaired cardiovascular …

[PDF][PDF] 复明片联合曲伏前列素滴眼液对原发性开角型青光眼患者眼部血流动力学和房水EPO, sCD44 的影响

乔淑琴, 王雪琼, 张晓兰, 关静… - Progress in Modern …, 2022 - biomed.cnjournals.com
摘要目的: 探讨复明片联合曲伏前列素滴眼液对原发性开角型青光眼(POAG)
患者眼部血流动力学和房水促红细胞生成素(EPO), 可溶性CD44 (sCD44) 的影响. 方法 …