[HTML][HTML] Current status of research on exosomes in general, and for the diagnosis and treatment of kidney cancer in particular

W Mao, K Wang, Z Wu, B Xu, M Chen - Journal of Experimental & Clinical …, 2021 - Springer
Kidney cancer is a common urological tumour. Owing to its high prevalence and mortality
rate, it is the third most malignant tumour of the urinary system, followed by prostate and …

Ratiometric 3D DNA machine combined with machine learning algorithm for ultrasensitive and high-precision screening of early urinary diseases

N Wu, XY Zhang, J Xia, X Li, T Yang, JH Wang - Acs Nano, 2021 - ACS Publications
Urinary extracellular vesicles (uEVs) have received considerable attention as a potential
biomarker source for the diagnosis of urinary diseases. Present studies mainly focus on the …

[HTML][HTML] Urinary extracellular vesicles as potential biomarkers for urologic cancers: An overview of current methods and advances

C Lourenço, V Constâncio, R Henrique, Â Carvalho… - Cancers, 2021 - mdpi.com
Simple Summary The diagnostic and monitoring techniques used for urologic cancers
comprise a group of invasive methodologies that still lack sensitivity and specificity …

[HTML][HTML] Mechanism of tumor‑derived extracellular vesicles in regulating renal cell carcinoma progression by the delivery of MALAT1

C Jin, L Shi, K Li, W Liu, Y Qiu, Y Zhao… - Oncology …, 2021 - spandidos-publications.com
Renal cell carcinoma (RCC) is a major healthcare burden globally. Tumor‑derived
extracellular vesicles (EVs) contribute to the formation of a pro‑metastatic microenvironment …

[HTML][HTML] miR-224-5p contained in urinary extracellular vesicles regulates PD-L1 expression by inhibiting cyclin D1 in renal cell carcinoma cells

Z Qin, H Hu, W Sun, L Chen, S Jin, Q Xu, Y Liu, L Yu… - Cancers, 2021 - mdpi.com
Simple Summary The detailed effects of abundant microRNAs contained in extracellular
vesicles (EVs) on renal cell carcinoma (RCC) progression are still unclear. This study …

[HTML][HTML] Extracellular vesicles in renal cell carcinoma: Challenges and opportunities coexist

Y Lu, M Zhang, J Zhou, X Liu, L Wang, X Hu… - Frontiers in …, 2023 - frontiersin.org
Renal cell carcinoma (RCC) represents an extremely challenging disease in terms of both
diagnosis and treatment. It poses a significant threat to human health, with incidence rates …

Exosomal microRNA‐15a from ACHN cells aggravates clear cell renal cell carcinoma via the BTG2/PI3K/AKT axis

DY Li, FF Lin, GP Li, FC Zeng - The Kaohsiung journal of …, 2021 - Wiley Online Library
Accumulating studies have indicated that exosomal microRNAs (miRNAs/miRs) can mediate
clear cell renal cell carcinoma (ccRCC) at the early stage, but the mechanisms remain to be …

[HTML][HTML] Advancements in the identification of EV derived mRNA biomarkers for liquid biopsy of clear cell renal cell carcinomas

MD Kuczler, RC Zieren, L Dong, TM de Reijke… - Urology, 2022 - Elsevier
Objective To propose EV-derived mRNA as a potential diagnostic biomarker detecting the
presence of clear cell renal cell carcinoma (ccRCC). There is currently no kidney cancer …

Recent advances in the molecular basis of chemotherapy resistance and potential application of epigenetic therapeutics in chemorefractory renal cell carcinoma

N Acharya, KP Singh - WIREs Mechanisms of Disease, 2022 - Wiley Online Library
Among various types of cancers, kidney cancer is unique with respect to a low frequency of
mutations and a relatively higher level of chemotherapy resistance. Resistance to …

[HTML][HTML] Extracellular vesicles in urological malignancies

MP Rimmer, CD Gregory, RT Mitchell - Biochimica et Biophysica Acta (BBA …, 2021 - Elsevier
Extracellular vesicles (EVs) are small lipid bound structures released from cells containing
bioactive cargoes. Both the type of cargo and amount loaded varies compared to that of the …