Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

The endoplasmic reticulum is an important intracellular organelle that plays an important
role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded …

The nod-like receptor protein-3 (NLRP3)-mediated pyroptosis is involved in kidney
diseases. Thioredoxin interacting protein (TXNIP) directly interacts with NLRP3. This study …

Endoplasmic reticulum (ER) stress, pyroptosis, and apoptosis are critical molecular events in
the occurrence and progress of renal ischemia reperfusion (I/R) injury. Naringenin (4′, 5, 7 …

Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …

Mitochondria and the endoplasmic reticulum (ER) are connected at multiple sites via what
are known as mitochondria-associated ER membranes (MAMs). These associations are …

Trimethylamine N-oxide (TMAO), a product of gut microbiota metabolism, has previously
been shown to be implicated in chronic kidney disease. A high TMAO-containing diet has …

Endoplasmic reticulum (ER) stress and mitochondrial dysfunction, which are key events in
the initiation and/or progression of several diseases, are correlated with alterations at ER …

Non-alcoholic fatty liver disease (NAFLD) is a common clinical disease, and its
pathogenesis is closely linked to oxidative stress and gut microbiota dysbiosis. Recently …

Ischemic stroke (also called cerebral ischemia) is one of the leading causes of death and
severe disability worldwide. NLR inflammasomes play a crucial role in sensing cell damage …