Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …

Autophagy in Human Health and Disease | NEJM Skip to main content NEJM Group Follow Us
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The most prevalent pathological features of many neurodegenerative diseases are the
aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy …

Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in
different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar …

Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more …

(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

Huntington's disease is a progressive, fatal, neurodegenerative disorder caused by an
expanded CAG repeat in the huntingtin gene, which encodes an abnormally long …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Huntington disease (HD) is a rare neurodegenerative disorder of the central nervous system
characterized by unwanted choreatic movements, behavioral and psychiatric disturbances …