The invention of chromosome conformation capture (3C) techniques, in particular the key
method Hi-C providing genome-wide information about chromatin contacts, revolutionized …

Determining how chromatin is structured in the nucleus is critical to studying its role in gene
regulation. Recent advances in the analysis of single-cell chromatin architecture have …

Abstract Single-cell Hi-C (scHi-C) technologies allow for probing of genome-wide cell-to-cell
variability in three-dimensional (3D) genome organization from individual cells …

Highlights•3D genome organization undergoes dramatic changes in cancer.•Oncogenes
can be ectopically activated by SV-induced enhancer hijacking.•Tumor suppressor genes …

Eukaryotic genomes are spatially organized inside the cell nucleus, forming a
threedimensional (3D) architecture that allows for spatial separation of nuclear processes …

Advances in chromatin mapping have exposed the complex chromatin hierarchical
organization in mammals, including topologically associating domains (TADs) and their …

Recent advances chromatin capture, imaging techniques, and polymer modeling have
dramatically enhanced quantitative understanding of chromosomal folding. However, the …

The proverbial “seeing is believing” is often easier said than done. Many of the most
fascinating aspects of nature can be difficult to visualize: to see distant stars requires …

The advent of personalized bone prosthesis materials and their integration into orthopedic
surgery has made a profound impact, primarily as a result of the incorporation of three …

Genome-wide association studies (GWAS) are powerful tools for identifying genetic variants
associated with complex diseases. However, their utility is limited in elucidating the genetics …