Tendinopathy is a multifactorial spectrum of tendon disorders that affects different
anatomical sites and is characterized by activity-related tendon pain. These disorders are …

The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …

As potent antigen-presenting cells, dendritic cells (DCs) comprise the most heterogeneous
cell population with significant cellular phenotypic and functional plasticity. They form a …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
in joints, associated with synovial hyperplasia and with bone and cartilage destruction …

Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the
earliest arrivals at target organs of disease. However, the role of NK cells in mounting …

CXCR3 is a G protein–coupled, seven‐transmembrane receptor that binds and is activated
by the three IFN‐γ‐inducible chemokines of the CXC family named CXCL9, CXCL10, and …

Connective tissues within the synovial joints are characterized by their dense extracellular
matrix and sparse cellularity. With injury or disease, however, tissues commonly experience …

A better understanding of the immunological processes governed by cytokines and
chemokines has shaped our approach to the design of therapeutics for diseases such as …

O sistema imunológico é constituído por uma intrincada rede de órgãos, células e
moléculas, e tem por finalidade manter a homeostase do organismo, combatendo as …

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, affecting almost 1% of
world population. Although the exact cause of RA is not known but the complex interaction …