Single nucleus multi-omics identifies human cortical cell regulatory genome diversity
Single-cell technologies measure unique cellular signatures but are typically limited to a
single modality. Computational approaches allow the fusion of diverse single-cell data …
single modality. Computational approaches allow the fusion of diverse single-cell data …
The ENIGMA Toolbox: multiscale neural contextualization of multisite neuroimaging datasets
Through harmonized procedures and by sharing site-specific brain metrics (for example,
cortical thickness) or aggregated statistical maps, ENIGMA has set the stage for large-scale …
cortical thickness) or aggregated statistical maps, ENIGMA has set the stage for large-scale …
A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles
NYA Sey, B Hu, W Mah, H Fauni, JC McAfee… - Nature …, 2020 - nature.com
Most risk variants for brain disorders identified by genome-wide association studies reside in
the noncoding genome, which makes deciphering biological mechanisms difficult. A …
the noncoding genome, which makes deciphering biological mechanisms difficult. A …
GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors
AR Docherty, N Mullins… - American journal of …, 2023 - Am Psychiatric Assoc
Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-
scale genome-wide association studies (GWASs) recently discovered and cross-validated …
scale genome-wide association studies (GWASs) recently discovered and cross-validated …
The genetic basis of major depression
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals
Differential DNA methylation in the brain is associated with many psychiatric diseases, but
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
W Van Rheenen, RAA Van Der Spek, MK Bakker… - Nature …, 2021 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
Genome-wide association studies have discovered hundreds of loci associated with
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …
GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores
Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis;
however, twin and family studies suggest that the genetic etiology of suicide attempt is …
however, twin and family studies suggest that the genetic etiology of suicide attempt is …
CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder
Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of
adults. While large-scale genetics studies have identified genomic regions associated with …
adults. While large-scale genetics studies have identified genomic regions associated with …