Arterial hypertension
S Brouwers, I Sudano, Y Kokubo, EM Sulaica - The Lancet, 2021 - thelancet.com
Arterial hypertension is the most important contributor to the global burden of disease;
however, disease control remains poor. Although the diagnosis of hypertension is still based …
however, disease control remains poor. Although the diagnosis of hypertension is still based …
Resistant hypertension: detection, evaluation, and management: a scientific statement from the American Heart Association
Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …
Preexisting comorbidities predicting COVID-19 and mortality in the UK biobank community cohort
JL Atkins, JAH Masoli, J Delgado… - The Journals of …, 2020 - academic.oup.com
Background Hospitalized COVID-19 patients tend to be older and frequently have
hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true …
hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
[HTML][HTML] Genome-wide association studies of brain imaging phenotypes in UK Biobank
The genetic architecture of brain structure and function is largely unknown. To investigate
this, we carried out genome-wide association studies of 3,144 functional and structural brain …
this, we carried out genome-wide association studies of 3,144 functional and structural brain …
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
E Evangelou, HR Warren, D Mosen-Ansorena… - Nature …, 2018 - nature.com
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …
disease. We report the largest genetic association study of blood pressure traits (systolic …
Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics
Mendelian randomization (MR) is a valuable tool for detecting causal effects by using
genetic variant associations. Opportunities to apply MR are growing rapidly with the …
genetic variant associations. Opportunities to apply MR are growing rapidly with the …
Association of age of onset of hypertension with cardiovascular diseases and mortality
C Wang, Y Yuan, M Zheng, AN Pan, M Wang… - Journal of the American …, 2020 - jacc.org
Background The relations of hypertension onset age with cardiovascular diseases (CVD)
and all-cause mortality remain inconclusive. Objectives This study sought to examine the …
and all-cause mortality remain inconclusive. Objectives This study sought to examine the …
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
The MR-Base platform supports systematic causal inference across the human phenome
Results from genome-wide association studies (GWAS) can be used to infer causal
relationships between phenotypes, using a strategy known as 2-sample Mendelian …
relationships between phenotypes, using a strategy known as 2-sample Mendelian …