[HTML][HTML] Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation

J Durack, NE Kimes, DL Lin, M Rauch… - Nature …, 2018 - nature.com
Gut microbiota dysbiosis and metabolic dysfunction in infancy precedes childhood atopy
and asthma development. Here we examined gut microbiota maturation over the first year of …

Steroid sulfatase inhibitors: the current landscape

HS Anbar, Z Isa, JJ Elounais, MA Jameel… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Steroid sulfatase (STS) enzyme is responsible for transforming the inactive
sulfate metabolites of steroid sex hormones into the active free steroids. Both the deficiency …

[HTML][HTML] Estradiol metabolism: crossroads in pulmonary arterial hypertension

SP Tofovic, EK Jackson - International journal of molecular sciences, 2019 - mdpi.com
Pulmonary arterial hypertension (PAH) is a debilitating and progressive disease that
predominantly develops in women. Over the past 15 years, cumulating evidence has …

[HTML][HTML] Novel associations between sex hormones and diabetic vascular complications in men and postmenopausal women: a cross-sectional study

C Wang, W Zhang, Y Wang, H Wan, Y Chen… - Cardiovascular …, 2019 - Springer
Background Associations between sex hormones and vascular remodeling have been
extensively studied, but the results vary widely among different races and sex. We aimed to …

[HTML][HTML] Is Estrogen a Missing Culprit in Thyroid Eye Disease? Sex Steroid Hormone Homeostasis Is Key to Other Fibrogenic Autoimmune Diseases–Why Not This …

AM FitzPatrick - Frontiers in Immunology, 2022 - frontiersin.org
Sex bias in autoimmune disease (AID) prevalence is known, but the role of estrogen in
disease progression is more complex. Estrogen can even be protective in some AIDs; but in …

[HTML][HTML] Role of gender in regulation of redox homeostasis in pulmonary arterial hypertension

R Rafikov, J James, N McClain, SP Tofovic, O Rafikova - Antioxidants, 2019 - mdpi.com
Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender
dimorphism. The prevalence of PAH is increased in females with a ratio of 4: 1, while poor …

Beyond oestrogens: towards a broader evaluation of the hormone profile in pulmonary arterial hypertension

JB Badlam, ED Austin - European Respiratory Journal, 2018 - Eur Respiratory Soc
Beyond oestrogens: towards a broader evaluation of the hormone profile in pulmonary arterial
hypertension | European Respiratory Society Skip to main content Main menu Home Current …

[PDF][PDF] 2-Methoxyestradiol Attenuates the Development and Retards the Progression of Hypoxia-And Alpha-Naphthylthiourea-Induced Pulmonary Hypertension

SP Tofovic, X Zhang, TJ Jones, G Petruševska - prilozi, 2021 - sciendo.com
Pulmonary arterial hypertension (PH), a progressive, incurable, and deadly disease,
predominantly develops in women. Growing body of evidence suggest that dysregulated …

[HTML][HTML] Sex and estrogen metabolism in Pulmonary Arterial Hypertension (PAH)

N Denver - 2020 - theses.gla.ac.uk
Pulmonary arterial hypertension (PAH) is a progressive, life-limiting disease, characterised
by increased pulmonary vascular resistance and right ventricular hypertrophy leading to …