[HTML][HTML] The epigenetics of neuropathic pain: A systematic update
Epigenetics deals with alterations to the gene expression that occur without change in the
nucleotide sequence in the DNA. Various covalent modifications of the DNA and/or the …
nucleotide sequence in the DNA. Various covalent modifications of the DNA and/or the …
[HTML][HTML] Potential therapeutic effects of short-chain fatty acids on chronic pain
Y Tang, J Du, H Wu, M Wang, S Liu… - Current …, 2023 - ncbi.nlm.nih.gov
The intestinal homeostasis maintained by the gut microbiome and relevant metabolites is
essential for health, and its disturbance leads to various intestinal or extraintestinal …
essential for health, and its disturbance leads to various intestinal or extraintestinal …
Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization
N Bauer, DI Balourdas, JR Schneider… - ACS chemical …, 2024 - ACS Publications
Bromodomain and extra-terminal domain (BET) proteins and histone deacetylases (HDACs)
are prime targets in cancer therapy. Recent research has particularly focused on the …
are prime targets in cancer therapy. Recent research has particularly focused on the …
Discovery of 1H-Imidazo[4,5-b]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain
X Chen, D Cao, C Liu, F Meng, Z Zhang… - Journal of medicinal …, 2023 - ACS Publications
Neuropathic pain (NP) is an intolerable pain syndrome that arises from continuous
inflammation and excitability after nerve injury. Only a few NP therapeutics are currently …
inflammation and excitability after nerve injury. Only a few NP therapeutics are currently …
[HTML][HTML] Zingiberene, a non-zinc-binding class I HDAC inhibitor: A novel strategy for the management of neuropathic pain
Abstract Background Even though numerous Histone deacetylase inhibitors (HDACi) have
been approved for the treatment of different types of cancer, and others are in clinical trials …
been approved for the treatment of different types of cancer, and others are in clinical trials …
[HTML][HTML] Global research trends on epigenetics and neuropathic pain: A bibliometric analysis
C Zhu, W Zhong, C Gong, B Chen… - Frontiers in Molecular …, 2023 - frontiersin.org
Objective Neuropathic pain (NP) is a common disease that manifests with pathological
changes in the somatosensory system. In recent years, the interactions of NP with the …
changes in the somatosensory system. In recent years, the interactions of NP with the …
[HTML][HTML] Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats
X Jia, J Ju, Z Li, X Peng, J Wang, F Gao - European Journal of …, 2024 - Elsevier
Background Morphine tolerance has been a challenging medical issue. Neuroinflammation
is considered as a critical mechanism for the development of morphine tolerance …
is considered as a critical mechanism for the development of morphine tolerance …
Targeting BRD4 with PROTAC degrader ameliorates LPS-induced acute lung injury by inhibiting M1 alveolar macrophage polarization
D Li, Y Deng, G Wen, L Wang, X Shi, S Chen… - International …, 2024 - Elsevier
Objectives Acute lung injury (ALI) is a highly inflammatory condition with the involvement of
M1 alveolar macrophages (AMs) polarization, eventually leading to the development of non …
M1 alveolar macrophages (AMs) polarization, eventually leading to the development of non …
[HTML][HTML] Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate …
J Zeng, WW Gao, H Yang, YN Wang, Y Mei… - European Journal of …, 2024 - Elsevier
The spinal cord microglia play a pivotal role in neuroinflammation and neuropathic pain
(NP). Sodium tanshinone IIA sulfonate (STS), a derivative of tanshinone IIA, has anti …
(NP). Sodium tanshinone IIA sulfonate (STS), a derivative of tanshinone IIA, has anti …
[HTML][HTML] Up-regulation of LCN2 in the anterior cingulate cortex contributes to neural injury-induced chronic pain
XJ Song, CL Yang, D Chen, Y Yang, Y Mao… - Frontiers in Cellular …, 2023 - frontiersin.org
Chronic pain caused by disease or injury affects more than 30% of the general population.
The molecular and cellular mechanisms underpinning the development of chronic pain …
The molecular and cellular mechanisms underpinning the development of chronic pain …