Cardiac fibrosis

NG Frangogiannis - Cardiovascular research, 2021 - academic.oup.com
Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Transforming growth factor-β in myocardial disease

NG Frangogiannis - Nature Reviews Cardiology, 2022 - nature.com
Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …

[HTML][HTML] Transforming growth factor–β in tissue fibrosis

NG Frangogiannis - Journal of Experimental Medicine, 2020 - rupress.org
TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

NG Frangogiannis - Molecular aspects of medicine, 2019 - Elsevier
Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Role of PI3K/Akt signaling pathway in cardiac fibrosis

W Qin, L Cao, IY Massey - Molecular and cellular biochemistry, 2021 - Springer
Heart failure (HF) is considered as a severe health problem worldwide, while cardiac fibrosis
is one of the main driving factors for the progress of HF. Cardiac fibrosis was characterized …

Immune cells and immunotherapy for cardiac injury and repair

JG Rurik, H Aghajanian, JA Epstein - Circulation research, 2021 - Am Heart Assoc
Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …

[HTML][HTML] Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

H Khalil, O Kanisicak, V Prasad… - The Journal of …, 2017 - Am Soc Clin Investig
The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue
injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete …

[HTML][HTML] Therapeutic targets for cardiac fibrosis: from old school to next-gen

JG Travers, CA Tharp, M Rubino… - The Journal of clinical …, 2022 - Am Soc Clin Investig
Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis

SD Prabhu, NG Frangogiannis - Circulation research, 2016 - Am Heart Assoc
In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

Cardiac fibrosis: the fibroblast awakens

JG Travers, FA Kamal, J Robbins, KE Yutzey… - Circulation …, 2016 - Am Heart Assoc
Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …