Rationale: Resistant hypertension is a major health concern with unknown cause.
Spironolactone is an effective antihypertensive drug, especially for patients with resistant …

Acute stimulation of cardiac β-adrenoceptors is crucial to increasing cardiac function under
stress; however, sustained β-adrenergic stimulation has been implicated in pathological …

The role of ion channels expressed in sensory neurons on mechanical and thermal
hyperalgesia was examined in a rat model of cisplatin-induced peripheral neuropathy. The …

The exact mechanism of the masseter muscle pain recognized as a prominent symptom in
temporomandibular disorders remains unclear, although it is clinically known that excessive …

ATP released from circulating erythrocytes is a potential signal regulating muscle blood flow
during exercise (exercise hyperemia), and intravascular ATP appears to blunt sympathetic …

Extracellular ATP acts on purinergic receptors as a potent agonist for a variety of different
cell types, including cardiomyocytes and nodose ganglia. P2X3 receptor is the most …

Nearly, all cells from very early life‐forms release ATP. ATP release is recognized
throughout the phylogenetic tree, being present in bacteria, yeasts, plants, prokaryotic single …

It is well known that cAMP, an important intracellular second messenger, is released from
many cells upon adenylate cyclase stimulation. Cell surface bound phosphodiesterase …

ATP is implicated in peripheral pain signaling by actions on P2X receptors, especially P2X3
receptor. Cardiac primary afferents running in the sympathetic nerves are considered to be …

目的通过心肌缺彬再灌注模型观察大鼠骨髓间充质干细胞心肌移植对心肌细胞外胶原,
小血管新生和心功能变化的影响, 并探讨其机制. 方法分离, 原代培养Wistar …