The Anrep effect is an adaptive response that increases left ventricular contractility following
an acute rise in afterload. Although the mechanistic origin remains undefined, recent …

Myofilament calcium (Ca2+) sensitivity is one of several mechanisms by which force
production of cardiac muscle is modulated to meet the ever-changing demands placed on …

Cardiac mechanical afterload induces an intrinsic autoregulatory increase in myocyte Ca2+
dynamics and contractility to enhance contraction (known as the Anrep effect or slow force …

Key points The Anrep effect represents the alteration of left ventricular (LV) contractility to
acutely enhanced afterload in a few seconds, thereby preserving stroke volume (SV) at …

Mechanical Control of Relaxation refers to the dependence of myocardial relaxation on the
strain rate just prior to relaxation, but the mechanisms of enhanced relaxation are not well …

The development of induced-pluripotent stem cell (iPSC)-derived cell types offers promise
for basic science, drug testing, disease modeling, personalized medicine, and translatable …

In cardiac muscle, intracellular Ca2+ transients activate contractile myofilaments, causing
contraction, macroscopic shortening, and geometric deformation. Our understanding of the …

Living cells navigate a complex landscape of mechanical cues that influence their behavior
and fate, originating from both internal and external sources. At the molecular level, the …

Several generations of cardiac physiologists have verified that basal cardiac contractility
depends strongly on the transsarcolemmal Na gradient, and the underlying molecular …

Aim Altered organization of the transverse‐tubular network is an early pathological event
occurring even prior to the onset of heart failure. Such t‐tubular remodelling disturbs the …