Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Long COVID: a review and proposed visualization of the complexity of long COVID

R Perumal, L Shunmugam, K Naidoo… - Frontiers in …, 2023 - frontiersin.org
Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus–2 (SARS-CoV-2)
infection, or Long COVID, is a prevailing second pandemic with nearly 100 million affected …

Obesity phenotypes and cardiovascular risk: from pathophysiology to clinical management

A Preda, F Carbone, A Tirandi, F Montecucco… - Reviews in Endocrine …, 2023 - Springer
Obesity epidemic reached the dimensions of a real global health crisis with more than one
billion people worldwide living with obesity. Multiple obesity-related mechanisms cause …

The role of pro-Inflammatory cytokines in the pathogenesis of cardiovascular disease

H Zhang, NS Dhalla - International Journal of Molecular Sciences, 2024 - mdpi.com
With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …

Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications

S Min, S Kim, WS Sim, YS Choi, H Joo, JH Park… - Nature …, 2024 - nature.com
Engineered human cardiac tissues have been utilized for various biomedical applications,
including drug testing, disease modeling, and regenerative medicine. However, the …

Emerging antiarrhythmic drugs for atrial fibrillation

A Saljic, J Heijman, D Dobrev - International Journal of Molecular …, 2022 - mdpi.com
Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, is driven by complex
mechanisms that differ between subgroups of patients. This complexity is apparent from the …

Protocatechuic acid prevents isoproterenol‐induced heart failure in mice by downregulating kynurenine‐3‐monooxygenase

L Bai, X Han, HJ Kee, X He, SH Kim… - Journal of Cellular …, 2023 - Wiley Online Library
Abstract Protocatechuic acid (3, 4‐dihydroxybenzoic acid) prevents oxidative stress,
inflammation and cardiac hypertrophy. This study aimed to investigate the therapeutic effects …

Noncoding RNAs: master regulator of fibroblast to myofibroblast transition in fibrosis

H Zhang, Y Zhou, D Wen, J Wang - International Journal of Molecular …, 2023 - mdpi.com
Myofibroblasts escape apoptosis and proliferate abnormally under pathological conditions,
especially fibrosis; they synthesize and secrete a large amount of extracellular matrix (ECM) …

Prostate cancer and microRNAs: New insights into apoptosis

J Gupta, WK Abdulsahib, AT Jalil, DS Kareem… - … -Research and Practice, 2023 - Elsevier
Prostate cancer (PCa) is known as one of the most prevalent malignancies globally and is
not yet curable owing to its progressive nature. It has been well documented that Genetic …

Progress and prospect of nanotechnology for cardiac fibrosis treatment

SL Gaytan, E Beaven, SS Gadad… - Interdisciplinary …, 2023 - Wiley Online Library
Cardiac fibrosis is the excessive accumulation of extracellular matrix components in the
heart, leading to reduced cardiac functionality and heart failure. This review provides an …