Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?
CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …
first-choice drug used daily by approximately 150 million people. An accumulation of …
Benefits of metformin in attenuating the hallmarks of aging
AS Kulkarni, S Gubbi, N Barzilai - Cell metabolism, 2020 - cell.com
Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …
[HTML][HTML] A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan
I Mohammed, MD Hollenberg, H Ding… - Frontiers in …, 2021 - frontiersin.org
The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
Targeting autophagy in disease: established and new strategies
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
[HTML][HTML] Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions
N Apostolova, F Iannantuoni, A Gruevska, J Muntane… - Redox biology, 2020 - Elsevier
Abstract Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder
closely related to atherosclerosis and cardiovascular diseases. It is characterised by …
closely related to atherosclerosis and cardiovascular diseases. It is characterised by …
The current and potential therapeutic use of metformin—the good old drug
J Drzewoski, M Hanefeld - Pharmaceuticals, 2021 - mdpi.com
Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …
Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled …
Progressive resistance exercise training (PRT) is the most effective known intervention for
combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is …
combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is …
The intersection of metformin and inflammation
LP Bharath, BS Nikolajczyk - American Journal of …, 2021 - journals.physiology.org
The biguanide metformin is the most commonly used antidiabetic drug. Recent studies show
that metformin not only improves chronic inflammation by improving metabolic parameters …
that metformin not only improves chronic inflammation by improving metabolic parameters …