Metformin and exercise both improve glycemic control, but in vitro studies have indicated
that an interaction between metformin and exercise occurs in skeletal muscle, suggesting a …

Metformin is the first-line treatment for type 2 diabetes. Inhibition of hepatic gluconeogenesis
is the primary contributor to its anti-diabetic effect. Metformin inhibits complex I and α …

The inversion of the pH gradient in malignant tumors, known as the pH paradigm, is
increasingly becoming accepted by the scientific community as a hallmark of cancer …

Abstract Introduction m. 3243A> G-related disease has multi-systemic manifestations
including diabetes mellitus. It is uncertain whether metformin would trigger neurological …

Interest in tumor cell mitochondria as a pharmacological target has been rekindled in recent
years. This attention is due in part to new publications documenting heterogenous …

Background Hepatic lipid accumulation is one of the main pathological features of alcoholic
liver disease (ALD). Metformin serves as an AMPK activator and has been shown to have …

A 40-year-old man with sensorineural hearing loss and diabetes mellitus was hospitalized
with acute-onset impaired consciousness and clumsiness in his left hand. He had been …

Metformin has been used for the treatment of type II diabetes mellitus for decades due to its
safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying …

Metformin has undisputed glucose-lowering effects in diabetes and an impressive safety
record. It has also shown promising effects beyond diabetes, and several hundred clinical …

Glaucoma is the leading cause of irreversible blindness globally. With an aging population,
disease incidence will rise with an enormous societal and economic burden. The treatment …